Expanding Treatment Options for Youth With Type 2 Diabetes: Current Problems and Proposed Solutions: A White Paper From the NICHD Diabetes Working Group

doi:10.2337/dc15-1649

. 2016 Mar;39(3):323-9.

doi: 10.2337/dc15-1649.

Expanding Treatment Options for Youth With Type 2 Diabetes: Current Problems and Proposed Solutions: A White Paper From the NICHD Diabetes Working Group

Collaborators, Affiliations

Collaborators

NICHD Diabetes Working Group:
Linda DiMeglio, Robert P Hoffman, Scott Blackman, Bruce Buckingham, Carine de Beaufort, Michael Freemark, Jon M Nakamoto, Aaron Kowalski, Nelly Mauras, Kristen Nadeau, Janet Snell-Bergeon, Steven Willi, William Tamborlane, Georgeanna Klingensmith, Kathleen Bethin, Jeffrey Blumer, David Dunger, Rose Gubitosi-Klug, Paula H Hale, Morey W Haymond, Janina Karres, Lori Laffel, Ingrid Libman, Ronald Portman, Ravi Shankar, Paolo Tomasi, Mark Rigby, Simi Ahmed, Craig Beam, Kasia Bourcier, Dana Dabelea, Carine de Beaufort, Mario Ehlers, Stephen Gitelman, Peter Gottlieb, Carla Greenbaum, Kevan Herold, Violeta Iotova, Rohit Kulkarni, Jeffrey Mahon, Elizabeth Mayer-Davis, James McNamara, Rama Natarajan, Trevor Orchard, William Russell, Jay Sosenko, Lisa Spain, Philip Zeitler, Fida Bacha, Silva Arslanian, Sonia Caprio, Christine Chan, Robert Chilton, Antonio Convit, Agnes Gyurasics, Tami Hannon, Daniel Hsia, Megan Moriarty Kelsey, Ingrid Libman, Jane Lynch, Zeina Melhem Nabhan, Kristen Nadeau, Catherine Pihoker, Michael Spigarelli, Eda Cengiz, Jeffrey Barrett, Jeffrey Blumer, Jenny Chien, Dennis Dietzen, Joga Gobburu, Robert P Hoffman, Holly Kimko, Tarek Leil, Ingrid Libman, Jon M Nakamoto, Michael Reed, Steven Russell, Paolo Tomasi

Affiliations

¹ Yale School of Medicine, New Haven, CT william.tamborlane@yale.edu.
² Baylor College of Medicine, Houston, TX.
³ University of Cambridge, Cambridge, U.K.
⁴ Merck & Company, Whitehouse Station, NJ.
⁵ University Hospitals Rainbow Babies and Children's Hospital, Cleveland, OH.
⁶ Women and Children's Hospital of Buffalo, Buffalo, NY.
⁷ European Medicines Agency, London, U.K.
⁸ Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, PA.
⁹ Novo Nordisk Inc., Bagsværd, Denmark.
¹⁰ Novartis Pharmaceuticals, East Hartford, CT.
¹¹ Barbara Davis Center for Childhood Diabetes, Aurora, CO.
¹² Akron Children's Hospital, Akron, OH.
¹³ University of Toledo, Toledo, OH.
¹⁴ National Institutes of Health, Bethesda, MD.

PMID: 26908928
PMCID: PMC4764039
DOI: 10.2337/dc15-1649

Expanding Treatment Options for Youth With Type 2 Diabetes: Current Problems and Proposed Solutions: A White Paper From the NICHD Diabetes Working Group

William V Tamborlane et al. Diabetes Care. 2016 Mar.

. 2016 Mar;39(3):323-9.

doi: 10.2337/dc15-1649.

Authors

Collaborators

NICHD Diabetes Working Group:
Linda DiMeglio, Robert P Hoffman, Scott Blackman, Bruce Buckingham, Carine de Beaufort, Michael Freemark, Jon M Nakamoto, Aaron Kowalski, Nelly Mauras, Kristen Nadeau, Janet Snell-Bergeon, Steven Willi, William Tamborlane, Georgeanna Klingensmith, Kathleen Bethin, Jeffrey Blumer, David Dunger, Rose Gubitosi-Klug, Paula H Hale, Morey W Haymond, Janina Karres, Lori Laffel, Ingrid Libman, Ronald Portman, Ravi Shankar, Paolo Tomasi, Mark Rigby, Simi Ahmed, Craig Beam, Kasia Bourcier, Dana Dabelea, Carine de Beaufort, Mario Ehlers, Stephen Gitelman, Peter Gottlieb, Carla Greenbaum, Kevan Herold, Violeta Iotova, Rohit Kulkarni, Jeffrey Mahon, Elizabeth Mayer-Davis, James McNamara, Rama Natarajan, Trevor Orchard, William Russell, Jay Sosenko, Lisa Spain, Philip Zeitler, Fida Bacha, Silva Arslanian, Sonia Caprio, Christine Chan, Robert Chilton, Antonio Convit, Agnes Gyurasics, Tami Hannon, Daniel Hsia, Megan Moriarty Kelsey, Ingrid Libman, Jane Lynch, Zeina Melhem Nabhan, Kristen Nadeau, Catherine Pihoker, Michael Spigarelli, Eda Cengiz, Jeffrey Barrett, Jeffrey Blumer, Jenny Chien, Dennis Dietzen, Joga Gobburu, Robert P Hoffman, Holly Kimko, Tarek Leil, Ingrid Libman, Jon M Nakamoto, Michael Reed, Steven Russell, Paolo Tomasi

Affiliations

¹ Yale School of Medicine, New Haven, CT william.tamborlane@yale.edu.
² Baylor College of Medicine, Houston, TX.
³ University of Cambridge, Cambridge, U.K.
⁴ Merck & Company, Whitehouse Station, NJ.
⁵ University Hospitals Rainbow Babies and Children's Hospital, Cleveland, OH.
⁶ Women and Children's Hospital of Buffalo, Buffalo, NY.
⁷ European Medicines Agency, London, U.K.
⁸ Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, PA.
⁹ Novo Nordisk Inc., Bagsværd, Denmark.
¹⁰ Novartis Pharmaceuticals, East Hartford, CT.
¹¹ Barbara Davis Center for Childhood Diabetes, Aurora, CO.
¹² Akron Children's Hospital, Akron, OH.
¹³ University of Toledo, Toledo, OH.
¹⁴ National Institutes of Health, Bethesda, MD.

PMID: 26908928
PMCID: PMC4764039
DOI: 10.2337/dc15-1649

No abstract available

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Figures

**Figure 1**
Example of a multi-agent study design of early combination therapies of pediatric T2D modeled after the TODAY study. DPP-4, dipeptidyl peptidase 4; GLP-1, glucagon-like peptide 1; SGLT2, sodium–glucose cotransporter 2.

See this image and copyright information in PMC

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References

1. Finkelstein JB. Pediatric drug trials facing some obstacles. J Natl Cancer Inst 2005;97:1720–1721 - PubMed
1. Zeitler P, Hirst K, Pyle L, et al. .; TODAY Study Group . A clinical trial to maintain glycemic control in youth with type 2 diabetes. N Engl J Med 2012;366:2247–2256 - PMC - PubMed
1. Gregg B, Connor CG, Ruedy KJ, et al.; Pediatric Diabetes Consortium. C-peptide levels in pediatric type 2 diabetes in the Pediatric Diabetes Consortium T2D Clinic Registry. Pediatr Diabetes. 5 May 2015 [Epub ahead of print]. DOI: 10.1111/pedi.12280 - PubMed
1. Tamborlane WV, Ruedy K, Van Name M, Klingensmith GJ. Can we get it right for youth with type 2 diabetes? Diabetes Res Clin Pract 2014;106:643–644 - PubMed
1. Karres J, Pratt V, Guettier JM, et al. . Joining forces: a call for greater collaboration to study new medicines in children and adolescents with type 2 diabetes. Diabetes Care 2014;37:2665–2667 - PubMed

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[1] Finkelstein JB. Pediatric drug trials facing some obstacles. J Natl Cancer Inst 2005;97:1720–1721 - PubMed

[2] Finkelstein JB. Pediatric drug trials facing some obstacles. J Natl Cancer Inst 2005;97:1720–1721 - PubMed

[3] Zeitler P, Hirst K, Pyle L, et al. .; TODAY Study Group . A clinical trial to maintain glycemic control in youth with type 2 diabetes. N Engl J Med 2012;366:2247–2256 - PMC - PubMed

[4] Zeitler P, Hirst K, Pyle L, et al. .; TODAY Study Group . A clinical trial to maintain glycemic control in youth with type 2 diabetes. N Engl J Med 2012;366:2247–2256 - PMC - PubMed

[5] Gregg B, Connor CG, Ruedy KJ, et al.; Pediatric Diabetes Consortium. C-peptide levels in pediatric type 2 diabetes in the Pediatric Diabetes Consortium T2D Clinic Registry. Pediatr Diabetes. 5 May 2015 [Epub ahead of print]. DOI: 10.1111/pedi.12280 - PubMed

[6] Gregg B, Connor CG, Ruedy KJ, et al.; Pediatric Diabetes Consortium. C-peptide levels in pediatric type 2 diabetes in the Pediatric Diabetes Consortium T2D Clinic Registry. Pediatr Diabetes. 5 May 2015 [Epub ahead of print]. DOI: 10.1111/pedi.12280 - PubMed

[7] Tamborlane WV, Ruedy K, Van Name M, Klingensmith GJ. Can we get it right for youth with type 2 diabetes? Diabetes Res Clin Pract 2014;106:643–644 - PubMed

[8] Tamborlane WV, Ruedy K, Van Name M, Klingensmith GJ. Can we get it right for youth with type 2 diabetes? Diabetes Res Clin Pract 2014;106:643–644 - PubMed

[9] Karres J, Pratt V, Guettier JM, et al. . Joining forces: a call for greater collaboration to study new medicines in children and adolescents with type 2 diabetes. Diabetes Care 2014;37:2665–2667 - PubMed

[10] Karres J, Pratt V, Guettier JM, et al. . Joining forces: a call for greater collaboration to study new medicines in children and adolescents with type 2 diabetes. Diabetes Care 2014;37:2665–2667 - PubMed

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Expanding Treatment Options for Youth With Type 2 Diabetes: Current Problems and Proposed Solutions: A White Paper From the NICHD Diabetes Working Group

Collaborators

Affiliations

Expanding Treatment Options for Youth With Type 2 Diabetes: Current Problems and Proposed Solutions: A White Paper From the NICHD Diabetes Working Group

Authors

Collaborators

Affiliations

Figures

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Cited by

References

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LinkOut - more resources

Full Text Sources

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