Obesity Reduces Cognitive and Motor Functions across the Lifespan

doi:10.1155/2016/2473081

Review

. 2016:2016:2473081.

doi: 10.1155/2016/2473081. Epub 2016 Jan 12.

Obesity Reduces Cognitive and Motor Functions across the Lifespan

Chuanming Wang¹, John S Y Chan², Lijie Ren³, Jin H Yan⁴

Affiliations

¹ Department of Neurology, The Affiliated Shenzhen Nanshan Hospital, Shenzhen University, Shenzhen 518000, China.
² Center for Brain Disorders and Cognitive Neuroscience, Shenzhen University, Shenzhen 518060, China; Department of Psychology, The Chinese University of Hong Kong, Shatin, Hong Kong.
³ Department of Neurology, Shenzhen Second People's Hospital, Shenzhen University, Shenzhen 518035, China.
⁴ Center for Brain Disorders and Cognitive Neuroscience, Shenzhen University, Shenzhen 518060, China.

PMID: 26881095
PMCID: PMC4737453
DOI: 10.1155/2016/2473081

Review

Obesity Reduces Cognitive and Motor Functions across the Lifespan

Chuanming Wang et al. Neural Plast. 2016.

. 2016:2016:2473081.

doi: 10.1155/2016/2473081. Epub 2016 Jan 12.

Authors

Chuanming Wang¹, John S Y Chan², Lijie Ren³, Jin H Yan⁴

Affiliations

¹ Department of Neurology, The Affiliated Shenzhen Nanshan Hospital, Shenzhen University, Shenzhen 518000, China.
² Center for Brain Disorders and Cognitive Neuroscience, Shenzhen University, Shenzhen 518060, China; Department of Psychology, The Chinese University of Hong Kong, Shatin, Hong Kong.
³ Department of Neurology, Shenzhen Second People's Hospital, Shenzhen University, Shenzhen 518035, China.
⁴ Center for Brain Disorders and Cognitive Neuroscience, Shenzhen University, Shenzhen 518060, China.

PMID: 26881095
PMCID: PMC4737453
DOI: 10.1155/2016/2473081

Abstract

Due to a sedentary lifestyle, more and more people are becoming obese nowadays. In addition to health-related problems, obesity can also impair cognition and motor performance. Previous results have shown that obesity mainly affects cognition and motor behaviors through altering brain functions and musculoskeletal system, respectively. Many factors, such as insulin/leptin dysregulation and inflammation, mediate the effect of obesity and cognition and motor behaviors. Substantial evidence has suggested exercise to be an effective way to improve obesity and related cognitive and motor dysfunctions. This paper aims to discuss the association of obesity with cognition and motor behaviors and its underlying mechanisms. Following this, mechanisms of exercise to improve obesity-related dysfunctions are described. Finally, implications and future research direction are raised.

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Figures

**Figure 1**
Factors mediating the effects of obesity and exercise on cognition and motor behaviors. Obesity affects cognition mainly through brain changes and influences motor behaviors through degrading the musculoskeletal system. Exercise can alleviate the deleterious effects of the obesity-related mediators on cognition and motor performance.

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References

1. Organization WHO. Obesity and overweight. World Health Organization, http://www.who.int/mediacentre/factsheets/fs311/en/
1. Bray G. A. Medical consequences of obesity. Journal of Clinical Endocrinology and Metabolism. 2004;89(6):2583–2589. doi: 10.1210/jc.2004-0535. - DOI - PubMed
1. Peeters A., Barendregt J. J., Willekens F., et al. Obesity in adulthood and its consequences for life expectancy: a life-table analysis. Annals of Internal Medicine. 2003;138(1):24–32. doi: 10.7326/0003-4819-138-1-200301070-00008. - DOI - PubMed
1. Reilly J. J., Methven E., McDowell Z. C., et al. Health consequences of obesity. Archives of Disease in Childhood. 2003;88(9):748–752. doi: 10.1136/adc.88.9.748. - DOI - PMC - PubMed
1. Must A., Strauss R. S. Risks and consequences of childhood and adolescent obesity. International Journal of Obesity and Related Metabolic Disorders. 1999;23(supplement 2):S2–S11. - PubMed

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[1] Organization WHO. Obesity and overweight. World Health Organization, http://www.who.int/mediacentre/factsheets/fs311/en/

[2] Organization WHO. Obesity and overweight. World Health Organization, http://www.who.int/mediacentre/factsheets/fs311/en/

[3] Bray G. A. Medical consequences of obesity. Journal of Clinical Endocrinology and Metabolism. 2004;89(6):2583–2589. doi: 10.1210/jc.2004-0535. - DOI - PubMed

[4] Bray G. A. Medical consequences of obesity. Journal of Clinical Endocrinology and Metabolism. 2004;89(6):2583–2589. doi: 10.1210/jc.2004-0535. - DOI - PubMed

[5] Peeters A., Barendregt J. J., Willekens F., et al. Obesity in adulthood and its consequences for life expectancy: a life-table analysis. Annals of Internal Medicine. 2003;138(1):24–32. doi: 10.7326/0003-4819-138-1-200301070-00008. - DOI - PubMed

[6] Peeters A., Barendregt J. J., Willekens F., et al. Obesity in adulthood and its consequences for life expectancy: a life-table analysis. Annals of Internal Medicine. 2003;138(1):24–32. doi: 10.7326/0003-4819-138-1-200301070-00008. - DOI - PubMed

[7] Reilly J. J., Methven E., McDowell Z. C., et al. Health consequences of obesity. Archives of Disease in Childhood. 2003;88(9):748–752. doi: 10.1136/adc.88.9.748. - DOI - PMC - PubMed

[8] Reilly J. J., Methven E., McDowell Z. C., et al. Health consequences of obesity. Archives of Disease in Childhood. 2003;88(9):748–752. doi: 10.1136/adc.88.9.748. - DOI - PMC - PubMed

[9] Must A., Strauss R. S. Risks and consequences of childhood and adolescent obesity. International Journal of Obesity and Related Metabolic Disorders. 1999;23(supplement 2):S2–S11. - PubMed

[10] Must A., Strauss R. S. Risks and consequences of childhood and adolescent obesity. International Journal of Obesity and Related Metabolic Disorders. 1999;23(supplement 2):S2–S11. - PubMed

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Obesity Reduces Cognitive and Motor Functions across the Lifespan

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Obesity Reduces Cognitive and Motor Functions across the Lifespan

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