Mechanisms of Selective Autophagy
- PMID: 26876603
- PMCID: PMC4871809
- DOI: 10.1016/j.jmb.2016.02.004
Mechanisms of Selective Autophagy
Abstract
Selective autophagy contributes to intracellular homeostasis by mediating the degradation of cytoplasmic material such as aggregated proteins, damaged or over-abundant organelles, and invading pathogens. The molecular machinery for selective autophagy must ensure efficient recognition and sequestration of the cargo within autophagosomes. Cargo specificity can be mediated by autophagic cargo receptors that specifically bind the cargo material and the autophagosomal membrane. Here we review the recent insights into the mechanisms that enable cargo receptors to confer selectivity and exclusivity to the autophagic process. We also discuss their different roles during starvation-induced and selective autophagy. We propose to classify autophagic events into cargo-independent and cargo-induced autophagosome formation events.
Keywords: Atg8; autophagosome; autophagy; cargo receptor; isolation membrane.
Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.
Figures
Similar articles
-
Interactions between autophagy receptors and ubiquitin-like proteins form the molecular basis for selective autophagy.Mol Cell. 2014 Jan 23;53(2):167-78. doi: 10.1016/j.molcel.2013.12.014. Mol Cell. 2014. PMID: 24462201 Review.
-
Autophagosome formation and cargo sequestration in the absence of LC3/GABARAPs.Autophagy. 2017 Apr 3;13(4):772-774. doi: 10.1080/15548627.2017.1281492. Epub 2017 Feb 6. Autophagy. 2017. PMID: 28165849 Free PMC article.
-
Mechanisms of Selective Autophagy in Normal Physiology and Cancer.J Mol Biol. 2016 May 8;428(9 Pt A):1659-80. doi: 10.1016/j.jmb.2016.02.027. Epub 2016 Mar 4. J Mol Biol. 2016. PMID: 26953261 Free PMC article. Review.
-
Selective Autophagy: ATG8 Family Proteins, LIR Motifs and Cargo Receptors.J Mol Biol. 2020 Jan 3;432(1):80-103. doi: 10.1016/j.jmb.2019.07.016. Epub 2019 Jul 13. J Mol Biol. 2020. PMID: 31310766 Review.
-
Molecular Mechanisms of Autophagy in Plants: Role of ATG8 Proteins in Formation and Functioning of Autophagosomes.Biochemistry (Mosc). 2016 Apr;81(4):348-63. doi: 10.1134/S0006297916040052. Biochemistry (Mosc). 2016. PMID: 27293092 Review.
Cited by
-
Harnessing autophagy: A potential breakthrough in digestive disease treatment.World J Gastroenterol. 2024 Jun 28;30(24):3036-3043. doi: 10.3748/wjg.v30.i24.3036. World J Gastroenterol. 2024. PMID: 38983959 Free PMC article. Review.
-
A hitchhiker's guide to autophagy.EMBO J. 2024 Aug;43(15):3087-3089. doi: 10.1038/s44318-024-00160-y. Epub 2024 Jul 4. EMBO J. 2024. PMID: 38965419 Free PMC article.
-
Styxl2 regulates de novo sarcomere assembly by binding to non-muscle myosin IIs and promoting their degradation.Elife. 2024 Jun 3;12:RP87434. doi: 10.7554/eLife.87434. Elife. 2024. PMID: 38829202 Free PMC article.
-
p62/sequestosome-1 as a severity-reflecting plasma biomarker in Charcot-Marie-Tooth disease type 1A.Sci Rep. 2024 May 14;14(1):10972. doi: 10.1038/s41598-024-61794-w. Sci Rep. 2024. PMID: 38745059 Free PMC article.
-
Autophagy in Its (Proper) Context: Molecular Basis, Biological Relevance, Pharmacological Modulation, and Lifestyle Medicine.Int J Biol Sci. 2024 Apr 22;20(7):2532-2554. doi: 10.7150/ijbs.95122. eCollection 2024. Int J Biol Sci. 2024. PMID: 38725847 Free PMC article. Review.
References
-
- Kraft C., Martens S. Mechanisms and regulation of autophagosome formation. Curr. Opin. Cell Biol. 2012;24(4):496–501. - PubMed
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources