Biodistribution, migration and homing of systemically applied mesenchymal stem/stromal cells

doi:10.1186/s13287-015-0271-2

Review

. 2016 Jan 11:7:7.

doi: 10.1186/s13287-015-0271-2.

Biodistribution, migration and homing of systemically applied mesenchymal stem/stromal cells

Johannes Leibacher¹, Reinhard Henschler^{2

3}

Affiliations

¹ Institute of Transfusion Medicine and Immune Hematology, German Red Cross Blood Donor Service, University of Frankfurt, Frankfurt, Germany.
² Institute of Transfusion Medicine and Immune Hematology, German Red Cross Blood Donor Service, University of Frankfurt, Frankfurt, Germany. rhenschler@gmx.de.
³ Blood Donor Center Zürich, Swiss Red Cross, Zürich, Switzerland. rhenschler@gmx.de.

PMID: 26753925
PMCID: PMC4709937
DOI: 10.1186/s13287-015-0271-2

Review

Biodistribution, migration and homing of systemically applied mesenchymal stem/stromal cells

Johannes Leibacher et al. Stem Cell Res Ther. 2016.

. 2016 Jan 11:7:7.

doi: 10.1186/s13287-015-0271-2.

Authors

Johannes Leibacher¹, Reinhard Henschler^{2

3}

Affiliations

¹ Institute of Transfusion Medicine and Immune Hematology, German Red Cross Blood Donor Service, University of Frankfurt, Frankfurt, Germany.
² Institute of Transfusion Medicine and Immune Hematology, German Red Cross Blood Donor Service, University of Frankfurt, Frankfurt, Germany. rhenschler@gmx.de.
³ Blood Donor Center Zürich, Swiss Red Cross, Zürich, Switzerland. rhenschler@gmx.de.

PMID: 26753925
PMCID: PMC4709937
DOI: 10.1186/s13287-015-0271-2

Abstract

Mesenchymal stem/stromal cells (MSCs) are increasingly used as an intravenously applied cellular therapeutic. They were found to be potent in situations such as tissue repair or severe inflammation. Still, data are lacking with regard to the biodistribution of MSCs, their cellular or molecular target structures, and the mechanisms by which MSCs reach these targets. This review discusses current hypotheses for how MSCs can reach tissue sites. Both preclinical and clinical studies using MSCs applied intravenously or intra-arterially are discussed in the context of our current understanding of how MSCs might work in physiological and pathological situations.

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Figures

**Fig. 1**
Possible ways that MSCs interact within the local environment of the bloodstream. Descriptions of cell types are shown below and the possible interactions are circled in *green. APC* antigen-presenting cell, EC endothelial cell, *IBMIR* instant blood mediated inflammatory response, *IFN* interferon, *MHC* major histocompatibility complex, *MSC* mesenchymal stem/stromal cell, NK natural killer, *Treg* regulatory T cell

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References

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1. Horwitz EM, Gordon PL, Koo WK, Marx JC, Neel MD, McNall RY, et al. Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: implications for cell therapy of bone. Proc Natl Acad Sci U S A. 2002;99:8932–7. doi: 10.1073/pnas.132252399. - DOI - PMC - PubMed

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[1] Friedenstein AJ, Chailakhyan RK, Latsinik NV, Panasyuk AF, Keiliss-Borok IV. Stromal cells responsible for transferring the micro-environment of the hemopoietic tissues. Cloning in vitro and retransplantation in vivo. Transplantation. 1974;17:331–40. doi: 10.1097/00007890-197404000-00001. - DOI - PubMed

[2] Friedenstein AJ, Chailakhyan RK, Latsinik NV, Panasyuk AF, Keiliss-Borok IV. Stromal cells responsible for transferring the micro-environment of the hemopoietic tissues. Cloning in vitro and retransplantation in vivo. Transplantation. 1974;17:331–40. doi: 10.1097/00007890-197404000-00001. - DOI - PubMed

[3] Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, et al. Multilineage potential of adult human mesenchymal stem cells. Science. 1999;284:143–7. doi: 10.1126/science.284.5411.143. - DOI - PubMed

[4] Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, et al. Multilineage potential of adult human mesenchymal stem cells. Science. 1999;284:143–7. doi: 10.1126/science.284.5411.143. - DOI - PubMed

[5] Caplan AI, Dennis JE. Mesenchymal stem cells as trophic mediators. J Cell Biochem. 2006;98:1076–84. doi: 10.1002/jcb.20886. - DOI - PubMed

[6] Caplan AI, Dennis JE. Mesenchymal stem cells as trophic mediators. J Cell Biochem. 2006;98:1076–84. doi: 10.1002/jcb.20886. - DOI - PubMed

[7] Caplan AI. Why are MSCs therapeutic? New data: new insight. J Pathol. 2009;217:318–24. doi: 10.1002/path.2469. - DOI - PMC - PubMed

[8] Caplan AI. Why are MSCs therapeutic? New data: new insight. J Pathol. 2009;217:318–24. doi: 10.1002/path.2469. - DOI - PMC - PubMed

[9] Horwitz EM, Gordon PL, Koo WK, Marx JC, Neel MD, McNall RY, et al. Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: implications for cell therapy of bone. Proc Natl Acad Sci U S A. 2002;99:8932–7. doi: 10.1073/pnas.132252399. - DOI - PMC - PubMed

[10] Horwitz EM, Gordon PL, Koo WK, Marx JC, Neel MD, McNall RY, et al. Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: implications for cell therapy of bone. Proc Natl Acad Sci U S A. 2002;99:8932–7. doi: 10.1073/pnas.132252399. - DOI - PMC - PubMed

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Biodistribution, migration and homing of systemically applied mesenchymal stem/stromal cells

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Biodistribution, migration and homing of systemically applied mesenchymal stem/stromal cells

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