TNFAIP3 and TNIP1 polymorphisms confer psoriasis risk in South Indian Tamils
- PMID: 26738398
- DOI: 10.1080/09674845.2015.11665748
TNFAIP3 and TNIP1 polymorphisms confer psoriasis risk in South Indian Tamils
Abstract
Psoriasis is a chronic inflammatory skin disease with genetic and environmental factors having an important role in its aetiology. Several genome-wide association studies have reported the association of the genes of the TNFα signalling, tumour necrosis factor alpha-induced protein 3 (TNFAIP3), TNFAIP3-interacting protein 1 (TNIP1) with psoriasis in Western and Chinese populations. The aim of this study is to demonstrate whether the TNFAIP3 and TNIP1 genes contribute to the risk of psoriasis in the ethnically distinct South Indian population. 360 psoriatic subjects and 360 healthy controls were recruited in this case control study. TNFAIP3 (rs610604) and TNIP1 (rs17728338) polymorphisms were typed by using TaqMan 5 allele discrimination assay. The results demonstrated that the SNPs rs610604 and rs17728338 of the TNFAIP3 and TNIP1 genes, respectively, were associated with psoriasis in our population at both allelic and genotypic levels. Thus, our results suggest that TNFAIP3 (rs610604) and TNIP1 (rs17728338) polymorphisms confer increased risk of psoriasis and may play a vital role in its pathogenesis in our ethnic South Indian Tamils.
Similar articles
-
Investigating the genetic association of HCP5, SPATA2, TNIP1, TNFAIP3 and COG6 with psoriasis in Chinese population.Int J Immunogenet. 2014 Dec;41(6):503-7. doi: 10.1111/iji.12150. Epub 2014 Sep 27. Int J Immunogenet. 2014. PMID: 25264125
-
Association of rs610604 in TNFAIP3 and rs17728338 in TNIP1 gene polymorphisms with psoriasis susceptibility: a meta-analysis of case-control studies.BMC Med Genet. 2020 May 12;21(1):103. doi: 10.1186/s12881-020-01041-x. BMC Med Genet. 2020. PMID: 32398022 Free PMC article.
-
TNFAIP3 and IL12B gene polymorphisms associated with psoriasis vulgaris in an Egyptian cohort.J Eur Acad Dermatol Venereol. 2015 Jul;29(7):1297-301. doi: 10.1111/jdv.12799. Epub 2014 Nov 18. J Eur Acad Dermatol Venereol. 2015. PMID: 25406098
-
Single nucleotide polymorphisms at the TNFAIP3/A20 locus and susceptibility/resistance to inflammatory and autoimmune diseases.Adv Exp Med Biol. 2014;809:163-83. doi: 10.1007/978-1-4939-0398-6_10. Adv Exp Med Biol. 2014. PMID: 25302371 Review.
-
Genetic relationships between A20/TNFAIP3, chronic inflammation and autoimmune disease.Biochem Soc Trans. 2011 Aug;39(4):1086-91. doi: 10.1042/BST0391086. Biochem Soc Trans. 2011. PMID: 21787353 Review.
Cited by
-
Interleukin-17 signaling triggers degradation of the constitutive NF-κB inhibitor ABIN-1.Immunohorizons. 2017 Sep;1(7):133-141. doi: 10.4049/immunohorizons.1700035. Immunohorizons. 2017. PMID: 30761389 Free PMC article.
-
Pharmacogenetic markers to predict the clinical response to methotrexate in south Indian Tamil patients with psoriasis.Eur J Clin Pharmacol. 2017 Aug;73(8):965-971. doi: 10.1007/s00228-017-2255-x. Epub 2017 Apr 25. Eur J Clin Pharmacol. 2017. PMID: 28444425
-
Mesenchymal Stem Cell Conditioned Media Ameliorate Psoriasis Vulgaris: A Case Study.Case Rep Dermatol Med. 2019 May 2;2019:8309103. doi: 10.1155/2019/8309103. eCollection 2019. Case Rep Dermatol Med. 2019. PMID: 31186972 Free PMC article.
-
The PANoptosome: A Deadly Protein Complex Driving Pyroptosis, Apoptosis, and Necroptosis (PANoptosis).Front Cell Infect Microbiol. 2020 Jun 3;10:238. doi: 10.3389/fcimb.2020.00238. eCollection 2020. Front Cell Infect Microbiol. 2020. PMID: 32582562 Free PMC article. Review.
-
TNFAIP3 genetic polymorphisms reduce ankylosing spondylitis risk in Eastern Chinese Han population.Sci Rep. 2019 Jul 15;9(1):10209. doi: 10.1038/s41598-019-46647-1. Sci Rep. 2019. PMID: 31308453 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Medical
Research Materials