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. 2016;38(5):527-33.
doi: 10.1080/13803395.2015.1132298. Epub 2016 Jan 6.

Greater memory impairment in dementing females than males relative to sex-matched healthy controls

Shawn D Gale  1   2 , Leslie Baxter  3 , Juliann Thompson  1
Affiliations

Greater memory impairment in dementing females than males relative to sex-matched healthy controls

Shawn D Gale et al. J Clin Exp Neuropsychol. 2016.

Abstract

Previously we demonstrated sex differences in episodic memory in healthy elderly and suggested that normative data be separated by sex. The present study extended the exploration of sex differences on memory measures into two clinical populations, mild cognitive impairment (MCI) and Alzheimer's disease (AD). Seventy-six subjects with MCI and 101 subjects with AD diagnosed by a multidisciplinary team were included. These two groups were also compared to a group of 177 healthy elderly control participants. Sex differences on the Rey Auditory Verbal Learning Test (RAVLT; total and delayed recall) raw scores and Brief Visuospatial Memory Test-Revised (BVMT-R) were demonstrated within the healthy but not the MCI or AD groups. Calculating z scores by sex for both dementing groups based on the healthy controls suggested a larger performance gap between healthy and dementing women than between healthy and dementing men. MCI females were on average 0.48 standard deviations lower for total verbal learning compared to healthy female controls than were MCI males when compared to healthy male controls. For verbal delayed recall the gap was even larger (SD = 1.09). Similarly, on the BVMT-R, a measure of visual memory, the difference was 0.60 standard deviations for total visual learning and 0.99 standard deviations for delayed recall. This same sex difference, with females showing greater impairment compared to the controls group than did the males, was also present within the AD group. The greater memory impairment in dementing females rather than males when compared to sex-matched healthy controls was unlikely to be due to more severe illness since females performed equivalently to males on the Clinical Dementia Rating Scale, Mini-Mental Status Examination, and Dementia Rating Scale, and were also similar for age, education, and apolipoprotein status. The present study suggested relatively greater memory impairment in females with MCI or AD than in controls.

Keywords: Memory; aging; dementia; mild cognitive impairment; sex.

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References

    1. Bai F, Zhang Z, Watson DR, Yu H, Shi Y, Zhu W, Qian Y. Absent gender differences of hippocampal atrophy in amnestic type mild cognitive impairment. Neurosci Lett. 2009;450(2):85–89. doi: 10.1016/j.neulet.2008.11.055. - DOI - PubMed
    1. Barnes LL, Wilson RS, Bienias JL, Schneider JA, Evans DA, Bennett DA. Sex differences in the clinical manifestations of Alzheimer disease pathology. Arch Gen Psychiatry. 2005;62(6):685–691. doi: 10.1001/archpsyc.62.6.685. - DOI - PubMed
    1. Barnes LL, Wilson RS, Schneider JA, Bienias JL, Evans DA, Bennett DA. Gender, cognitive decline, and risk of AD in older persons. Neurology. 2003;60(11):1777–1781. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dop.... - PubMed
    1. Benedict HRB. Brief Visuospatial Memory Test-Revised professional manual. Odessa Florida: Psychological Assessment Resources, Inc; 1997.
    1. Benton AD, Hamsher K. Multilingual Aphasia Examination. Iowa City: University of Iowa Press; 1976.

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