Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Observational Study
. 2017 Nov;11(6):839-846.
doi: 10.1111/crj.12425. Epub 2016 Jan 6.

Oxidative stress and inflamatory plasma biomarkers in respiratory syncytial virus bronchiolitis

Gloria Moreno-Solís  1 , María José Dela Torre-Aguilar  2 , Javier Torres-Borrego  1 , Francisco Jesus Llorente-Cantarero  2 , Fernando Fernández-Gutiérrez  3 , Mercedes Gil-Campos  2   3 , Isaac Túnez-Fiñana  2 , Juan Luis Pérez-Navero  2   3
Affiliations
Observational Study

Oxidative stress and inflamatory plasma biomarkers in respiratory syncytial virus bronchiolitis

Gloria Moreno-Solís et al. Clin Respir J. 2017 Nov.

Abstract

Introduction: Oxidative stress (OS) plays a crucial role in the pathogenesis of inflammatory lung diseases.

Objectives: (i) We determined whether acute bronchiolitis (AB) caused by respiratory syncytial virus (RSV) induced OS; (ii) assessed whether OS biomarkers correlated with the severity of RSV-AB; and (iii) studied whether the levels of interleukins are associated with OS biomarkers.

Methods: We performed an observational study by comparing healthy infants (Group 1) with RSV-AB infants, classified as Group 2 (pulse oximetry (SpO2 ) >93%), and Group 3 (SpO2 ≤ 92%), which needed oxygen therapy. Blood samples were collected to determine the levels of lipid peroxidation (LPO) products (LPO), total glutathione (TG), oxidised glutathione (GSSG), reduced glutathione (GSH), glutathione peroxidase (GPx), interleukins (ILs) IL-10, IL-6, IL-8, interferon-gamma (IFNγ), tumour necrosis factor-alpha (TNFα) and macrophage inflammatory proteins (MIP α and MIP β).

Results: Forty-six RSV-AB infants (47% needed oxygen therapy) and 27 healthy infants were included. The GSH/GSSG ratio was lower in RSV-AB infants than in Group 1 (P<0.001). GSSG and GPx were significantly higher in Group 3. GSSG predicted the need for oxygen therapy with an optimal cut-off point of 15 µM/g for haemoglobin. The GSH/GSSG ratio negatively correlated with IL-6 (P: 0.014), IL-8 (P: 0.014) and IL-10 (P: 0.033). Group 3 exhibited a direct correlation between GPx and IL-10 levels (P: 0.024) and between LPO and MIP β (P: 0.003).

Conclusions: RSV induced OS in AB. An increase in GSSG correlated with the disease severity in the infants. OS may contribute to the pathogenesis of RSV-AB.

Keywords: Interleukins; bronchiolitis; oxidative stress; respiratory syncytial virus.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources