Increased carotid intima-media thickness in rheumatoid arthritis: an update meta-analysis

doi:10.1007/s10067-015-3130-8

Meta-Analysis

. 2016 Feb;35(2):315-23.

doi: 10.1007/s10067-015-3130-8. Epub 2015 Nov 27.

Increased carotid intima-media thickness in rheumatoid arthritis: an update meta-analysis

Peng Wang^{1

2}, Shi-Yang Guan^{1

2}, Shu-Zhen Xu^{1

2}, Hong-Miao Li^{1

2}, Rui-Xue Leng^{1

2}, Xiang-Pei Li³, Hai-Feng Pan^{4

5}

Affiliations

¹ Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, People's Republic of China.
² Anhui provincial laboratory of population health and major disease screening and diagnosis, Anhui, 230032, People's Republic of China.
³ Department of Rheumatology, Anhui Provincial Hospital, Hefei, China.
⁴ Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, People's Republic of China. panhaifeng1982@sina.com.
⁵ Anhui provincial laboratory of population health and major disease screening and diagnosis, Anhui, 230032, People's Republic of China. panhaifeng1982@sina.com.

PMID: 26614535
DOI: 10.1007/s10067-015-3130-8

Meta-Analysis

Increased carotid intima-media thickness in rheumatoid arthritis: an update meta-analysis

Peng Wang et al. Clin Rheumatol. 2016 Feb.

. 2016 Feb;35(2):315-23.

doi: 10.1007/s10067-015-3130-8. Epub 2015 Nov 27.

Authors

Peng Wang^{1

2}, Shi-Yang Guan^{1

2}, Shu-Zhen Xu^{1

2}, Hong-Miao Li^{1

2}, Rui-Xue Leng^{1

2}, Xiang-Pei Li³, Hai-Feng Pan^{4

5}

Affiliations

¹ Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, People's Republic of China.
² Anhui provincial laboratory of population health and major disease screening and diagnosis, Anhui, 230032, People's Republic of China.
³ Department of Rheumatology, Anhui Provincial Hospital, Hefei, China.
⁴ Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, People's Republic of China. panhaifeng1982@sina.com.
⁵ Anhui provincial laboratory of population health and major disease screening and diagnosis, Anhui, 230032, People's Republic of China. panhaifeng1982@sina.com.

PMID: 26614535
DOI: 10.1007/s10067-015-3130-8

Abstract

This study aims to derive a more precise estimation on carotid intima-media thickness (CIMT) level in patients with rheumatoid arthritis (RA) and related factors. Studies published from January 1, 1982 to December 31, 2014 in English, which comparing CIMT between RA group and control group were searched in PubMed, Embase, and Cochrane Library databases. Heterogeneity test was performed, and publication bias was evaluated. Stata software 12.0 was used to perform the meta-analysis. Two-thousand one hundred sixty-three articles were obtained after searching databases, and 47 studies were finally included in the meta-analysis. The result of the analysis in random effect model showed that RA group had significantly higher CIMT than control group, with the standardized mean difference (SMD) of 1.04 and 95% CI (0.81,1.27). To evaluate the stability of our results, sensitivity analyses were performed, and the results showed no significant change when any one study was excluded. Subgroup analyses showed that region, race, age, BMI, and disease duration were associated with CIMT in RA patients. In summary, CIMT in RA patients is thicker than healthy controls, and it is influenced by region, race, age, BMI, and disease duration.

Keywords: Carotid intima-media thickness; Meta-analysis; Rheumatoid arthritis.

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References

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[1] Ann Rheum Dis. 2014 Apr;73(4):722-7 - PubMed

[2] Ann Rheum Dis. 2014 Apr;73(4):722-7 - PubMed

[3] Atherosclerosis. 2008 Jun;198(2):332-7 - PubMed

[4] Atherosclerosis. 2008 Jun;198(2):332-7 - PubMed

[5] J Epidemiol Community Health. 2005 Oct;59(10):864-9 - PubMed

[6] J Epidemiol Community Health. 2005 Oct;59(10):864-9 - PubMed

[7] J Rheumatol. 2010 Apr;37(4):730-9 - PubMed

[8] J Rheumatol. 2010 Apr;37(4):730-9 - PubMed

[9] Stat Med. 2002 Jun 15;21(11):1539-58 - PubMed

[10] Stat Med. 2002 Jun 15;21(11):1539-58 - PubMed

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Increased carotid intima-media thickness in rheumatoid arthritis: an update meta-analysis

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Increased carotid intima-media thickness in rheumatoid arthritis: an update meta-analysis

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