doi: 10.1002/sim.4780080504.
Flexible regression models with cubic splines
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- PMID: 2657958
- DOI: 10.1002/sim.4780080504
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Flexible regression models with cubic splines
Stat Med.
1989 May.
Abstract
We describe the use of cubic splines in regression models to represent the relationship between the response variable and a vector of covariates. This simple method can help prevent the problems that result from inappropriate linearity assumptions. We compare restricted cubic spline regression to non-parametric procedures for characterizing the relationship between age and survival in the Stanford Heart Transplant data. We also provide an illustrative example in cancer therapeutics.
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