Roles of Wnt Signaling in the Neurogenic Niche of the Adult Mouse Ventricular-Subventricular Zone

doi:10.1007/s11064-015-1766-z

Review

. 2016 Feb;41(1-2):222-30.

doi: 10.1007/s11064-015-1766-z. Epub 2015 Nov 16.

Roles of Wnt Signaling in the Neurogenic Niche of the Adult Mouse Ventricular-Subventricular Zone

Yuki Hirota¹, Masato Sawada¹, Shih-Hui Huang¹, Takashi Ogino¹, Shinya Ohata², Akiharu Kubo³, Kazunobu Sawamoto⁴

Affiliations

¹ Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, 467-8601, Japan.
² Laboratory of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, 113-0033, Japan.
³ Department of Dermatology, Keio University School of Medicine, Tokyo, 160-8582, Japan.
⁴ Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, 467-8601, Japan. sawamoto@med.nagoya-cu.ac.jp.

PMID: 26572545
DOI: 10.1007/s11064-015-1766-z

Review

Roles of Wnt Signaling in the Neurogenic Niche of the Adult Mouse Ventricular-Subventricular Zone

Yuki Hirota et al. Neurochem Res. 2016 Feb.

. 2016 Feb;41(1-2):222-30.

doi: 10.1007/s11064-015-1766-z. Epub 2015 Nov 16.

Authors

Yuki Hirota¹, Masato Sawada¹, Shih-Hui Huang¹, Takashi Ogino¹, Shinya Ohata², Akiharu Kubo³, Kazunobu Sawamoto⁴

Affiliations

¹ Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, 467-8601, Japan.
² Laboratory of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, 113-0033, Japan.
³ Department of Dermatology, Keio University School of Medicine, Tokyo, 160-8582, Japan.
⁴ Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, 467-8601, Japan. sawamoto@med.nagoya-cu.ac.jp.

PMID: 26572545
DOI: 10.1007/s11064-015-1766-z

Abstract

In many animal species, the production of new neurons (neurogenesis) occurs throughout life, in a specialized germinal region called the ventricular-subventricular zone (V-SVZ). In this region, neural stem cells undergo self-renewal and generate neural progenitor cells and new neurons. In the olfactory system, the new neurons migrate rostrally toward the olfactory bulb, where they differentiate into mature interneurons. V-SVZ-derived new neurons can also migrate toward sites of brain injury, where they contribute to neural regeneration. Recent studies indicate that two major branches of the Wnt signaling pathway, the Wnt/β-catenin and Wnt/planar cell polarity pathways, play essential roles in various facets of adult neurogenesis. Here, we review the Wnt signaling-mediated regulation of adult neurogenesis in the V-SVZ under physiological and pathological conditions.

Keywords: Adult neurogenesis; Neural stem cells; Planar cell polarity; Regeneration; Ventricular–subventricular zone; Wnt signaling; β-Catenin.

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References

1. Stem Cells. 2014 May;32(5):1301-12 - PubMed
1. Neuropharmacology. 2010 May;58(6):877-83 - PubMed
1. Science. 2006 Feb 3;311(5761):629-32 - PubMed
1. Nat Cell Biol. 2010 Jan;12(1):31-40; sup pp 1-9 - PubMed
1. Stem Cells. 2011 Mar;29(3):528-38 - PubMed

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[1] Stem Cells. 2014 May;32(5):1301-12 - PubMed

[2] Stem Cells. 2014 May;32(5):1301-12 - PubMed

[3] Neuropharmacology. 2010 May;58(6):877-83 - PubMed

[4] Neuropharmacology. 2010 May;58(6):877-83 - PubMed

[5] Science. 2006 Feb 3;311(5761):629-32 - PubMed

[6] Science. 2006 Feb 3;311(5761):629-32 - PubMed

[7] Nat Cell Biol. 2010 Jan;12(1):31-40; sup pp 1-9 - PubMed

[8] Nat Cell Biol. 2010 Jan;12(1):31-40; sup pp 1-9 - PubMed

[9] Stem Cells. 2011 Mar;29(3):528-38 - PubMed

[10] Stem Cells. 2011 Mar;29(3):528-38 - PubMed

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Roles of Wnt Signaling in the Neurogenic Niche of the Adult Mouse Ventricular-Subventricular Zone

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Roles of Wnt Signaling in the Neurogenic Niche of the Adult Mouse Ventricular-Subventricular Zone

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