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Review
. 2015 Nov 11;5(4):3051-66.
doi: 10.3390/biom5043051.

Expression and Function of CD44 in Epithelial Ovarian Carcinoma

Joelle D Sacks  1 , Maria V Barbolina  2
Affiliations
Review

Expression and Function of CD44 in Epithelial Ovarian Carcinoma

Joelle D Sacks et al. Biomolecules. .

Abstract

CD44, a cell surface glycoprotein, has been increasingly implicated in the pathogenesis and progression of epithelial ovarian cancer, the deadliest gynecologic malignancy in women. Here, we review recent reports on the expression and function of CD44 in epithelial ovarian carcinoma. Further functional data for CD44 in peritoneal adhesion and metastatic progression and its association with stem cells is highlighted. Recent studies utilizing CD44 for therapeutic targeting are also discussed.

Keywords: CD44; adhesion; cancer stem cells; epithelial ovarian carcinoma; hyaluronan; metastasis.

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Figures

Figure 1
Figure 1
CD44 mRNA Transcripts. CD44 pre-mRNA is encoded by 20 exons, 10 of which can be regulated by alternative splicing of variant exons. The smallest CD44 isoform, which is known as CD44 standard (CD44s), includes only standard exons 1–5 and 6–10. CD44 variant isoforms include the addition of a combination of variant exons v1–v10 [6].
See this image and copyright information in PMC

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