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. 2016 Jan 15;576(1 Pt 2):339-46.
doi: 10.1016/j.gene.2015.10.072. Epub 2015 Nov 11.

Serum and glucocorticoid kinase 1 promoted the growth and migration of non-small cell lung cancer cells

Yu Xiaobo  1 , Lin Qiang  2 , Qin Xiong  1 , Ruan Zheng  1 , Zhou Jianhua  1 , Lin Zhifeng  1 , Su Yijiang  1 , Jian Zheng  1
Affiliations

Serum and glucocorticoid kinase 1 promoted the growth and migration of non-small cell lung cancer cells

Yu Xiaobo et al. Gene. .

Abstract

Serum and glucocorticoid kinase 1 (SGK1) has been reported to be up-regulated in non-small cell lung cancer (NSCLC). However, its functions in NSCLC remained unclear. Here, SGK1 was found to be up-regulated in NSCLC samples. Over-expression of SGK1 promoted the growth and migration of NSCLC cells, while down-regulation of SGK1 inhibited the growth, migration and metastasis of NSCLC cells. SGK1 promoted the phosphorylation of GSK3 beta and the accumulation of beta-catenin, up-regulation of the target genes downstream of beta-catenin/TCF signaling, and activating the transcriptional activity of beta-catenin/TCF complex. Collectively, SGK1 might promote the progression of NSCLC through activating beta-catenin/TCF signaling.

Keywords: Beta-catenin/TCF signaling; Cell growth and migration; NSCLC; SGK1.

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