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Review
. 2016 Jan;99(1):92-100.
doi: 10.1002/cpt.277. Epub 2015 Nov 23.

Pharmacoepidemiologic Methods for Studying the Health Effects of Drug-Drug Interactions

S Hennessy  1 , C E Leonard  1 , J J Gagne  2 , J H Flory  1   3   4 , X Han  1 , C M Brensinger  1 , W B Bilker  1
Affiliations
Review

Pharmacoepidemiologic Methods for Studying the Health Effects of Drug-Drug Interactions

S Hennessy et al. Clin Pharmacol Ther. 2016 Jan.

Abstract

A drug-drug interaction (DDI) occurs when one or more drugs affect the pharmacokinetics (the body's effect on the drug) and/or pharmacodynamics (the drug's effect on the body) of one or more other drugs. Pharmacoepidemiologic studies are the principal way of studying the health effects of potential DDIs. This article discusses aspects of pharmacoepidemiologic research designs that are particularly salient to the design and interpretation of pharmacoepidemiologic studies of DDIs.

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Conflict of interest statement

Conflict of Interest / Disclosure

SH receives salary support through his employer for a study funded by AstraZeneca and Bristol-Myers Squibb, oversees a pharmacoepidemiology training program that receives support from Pfizer Inc and Sanofi, and in the past year has served as a consultant to Abbvie Inc, Merck Sharpe & Dohme Corp, Collegium Pharmaceutical Inc and a law firm representing Hoffman-LaRoche. JJG is a consultant to Aetion, Inc., a software company. WBB serves as a consultant to Johnson & Johnson. None of the other authors reports relevant relationships.

Figures

Figure 1
Figure 1
Schematic depiction the two different potential time-courses of a precipitant-triggered drug-drug interaction.
Figure 1
Figure 1
Schematic depiction the two different potential time-courses of a precipitant-triggered drug-drug interaction.
See this image and copyright information in PMC

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