MiR-455-3p regulates early chondrogenic differentiation via inhibiting Runx2
- PMID: 26474644
- DOI: 10.1016/j.febslet.2015.09.032
MiR-455-3p regulates early chondrogenic differentiation via inhibiting Runx2
Abstract
The expression of miR-455-3p has been shown to be up-regulated in chondrogenesis of mesenchymal stem cell, but its role in different stages during chondrogenesis remains unknown. Here, we show that miR-455-3p is increased in ATDC5 cells from 0 d to 21 d, but rapidly decreases at 28 d, and a similar expression kinetic is detected in the development of mouse embryos. We show that miR-455-3p functions as an activator for early chondrogenic differentiation, most likely by inhibiting the expression of Runt-related transcription factor 2 (Runx2) as indicated by luciferase reporter assays. In conclusion, miR-455-3p may activate early chondrogenesis by directly targeting Runx2.
Keywords: Chondrogenesis; MiR-455-3p; Runt-related transcription factor 2.
Copyright © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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