Nonmutagenic carcinogens induce intrachromosomal recombination in yeast
- PMID: 2643057
- DOI: 10.1038/337285a0
Nonmutagenic carcinogens induce intrachromosomal recombination in yeast
Abstract
To identify environmental carcinogens there is a need for inexpensive and reliable short-term tests, but certain human or animal carcinogens are persistently undetectable as mutagents with the Ames assay or with other short-term tests currently in use. Thus there is a need for short-term tests which detect carcinogens missed by the Ames assay. Because of the association of carcinogenesis with genome rearrangement, a system screening for intrachromosomal recombination resulting in genome rearrangement has been constructed in Saccharomyces cerevisiae. Evaluation of this system shows inducibility by a variety of carcinogens not detectable by the Ames assay or various other short-term tests. In the light of these results it is tempting to speculate that 'nongenotoxic carcinogens' are in fact genotoxic but, in the past, the tools to measure the genetic alterations they induce have been inappropriate.
Similar articles
-
Carcinogens induce intrachromosomal recombination in yeast.Carcinogenesis. 1989 Aug;10(8):1445-55. doi: 10.1093/carcin/10.8.1445. Carcinogenesis. 1989. PMID: 2665967
-
Nonmutagenic carcinogens induce intrachromosomal recombination in dividing yeast cells.Environ Health Perspect. 1993 Dec;101 Suppl 5(Suppl 5):179-84. doi: 10.1289/ehp.93101s5179. Environ Health Perspect. 1993. PMID: 8013407 Free PMC article.
-
Adaptive resistance of Saccharomyces cerevisiae to chronic treatment with genotoxic and nongenotoxic carcinogens.J Environ Pathol Toxicol Oncol. 1999;18(2):103-8. J Environ Pathol Toxicol Oncol. 1999. PMID: 15281221
-
Short-term tests for mutagenesis and carcinogenesis in drug toxicology: how to test and when to test is the question.Drug Metab Rev. 1980;11(1):103-46. doi: 10.3109/03602538008994023. Drug Metab Rev. 1980. PMID: 6448737 Review. No abstract available.
-
International Commission for Protection against Environmental Mutagens and Carcinogens. Committee 2 Final Report. Mutagenesis testing as an approach to carcinogenesis.Mutat Res. 1982 Jul;99(1):73-91. Mutat Res. 1982. PMID: 6214712 Review. No abstract available.
Cited by
-
Oxidative stress is involved in heat-induced cell death in Saccharomyces cerevisiae.Proc Natl Acad Sci U S A. 1996 May 14;93(10):5116-21. doi: 10.1073/pnas.93.10.5116. Proc Natl Acad Sci U S A. 1996. PMID: 8643537 Free PMC article.
-
Interchromosomal and intrachromosomal recombination in rad 18 mutants of Saccharomyces cerevisiae.Mol Gen Genet. 1990 Jun;222(1):25-32. doi: 10.1007/BF00283018. Mol Gen Genet. 1990. PMID: 2233677
-
Ku-dependent and Ku-independent end-joining pathways lead to chromosomal rearrangements during double-strand break repair in Saccharomyces cerevisiae.Genetics. 2003 Mar;163(3):843-56. doi: 10.1093/genetics/163.3.843. Genetics. 2003. PMID: 12663527 Free PMC article.
-
Expression of cancer related BRCA1 missense variants decreases MMS-induced recombination in Saccharomyces cerevisiae without altering its nuclear localization.Cell Cycle. 2016 Oct 17;15(20):2723-31. doi: 10.1080/15384101.2016.1215389. Epub 2016 Aug 2. Cell Cycle. 2016. PMID: 27484786 Free PMC article.
-
Induction of hepatic tumors with butylated hydroxyanisole in the self-fertilizing hermaphroditic fish Rivulus ocellatus marmoratus.Jpn J Cancer Res. 1990 Aug;81(8):738-41. doi: 10.1111/j.1349-7006.1990.tb02638.x. Jpn J Cancer Res. 1990. PMID: 2118888 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous
