Early infancy microbial and metabolic alterations affect risk of childhood asthma
- PMID: 26424567
- DOI: 10.1126/scitranslmed.aab2271
Early infancy microbial and metabolic alterations affect risk of childhood asthma
Abstract
Asthma is the most prevalent pediatric chronic disease and affects more than 300 million people worldwide. Recent evidence in mice has identified a "critical window" early in life where gut microbial changes (dysbiosis) are most influential in experimental asthma. However, current research has yet to establish whether these changes precede or are involved in human asthma. We compared the gut microbiota of 319 subjects enrolled in the Canadian Healthy Infant Longitudinal Development (CHILD) Study, and show that infants at risk of asthma exhibited transient gut microbial dysbiosis during the first 100 days of life. The relative abundance of the bacterial genera Lachnospira, Veillonella, Faecalibacterium, and Rothia was significantly decreased in children at risk of asthma. This reduction in bacterial taxa was accompanied by reduced levels of fecal acetate and dysregulation of enterohepatic metabolites. Inoculation of germ-free mice with these four bacterial taxa ameliorated airway inflammation in their adult progeny, demonstrating a causal role of these bacterial taxa in averting asthma development. These results enhance the potential for future microbe-based diagnostics and therapies, potentially in the form of probiotics, to prevent the development of asthma and other related allergic diseases in children.
Copyright © 2015, American Association for the Advancement of Science.
Comment in
-
Asthma: Undoing millions of years of coevolution in early life?Sci Transl Med. 2015 Sep 30;7(307):307fs39. doi: 10.1126/scitranslmed.aad2741. Sci Transl Med. 2015. PMID: 26424565 No abstract available.
Similar articles
-
Emerging evidence of the role of gut microbiota in the development of allergic diseases.Curr Opin Allergy Clin Immunol. 2016 Aug;16(4):390-5. doi: 10.1097/ACI.0000000000000277. Curr Opin Allergy Clin Immunol. 2016. PMID: 27253486 Review.
-
Associations between infant fungal and bacterial dysbiosis and childhood atopic wheeze in a nonindustrialized setting.J Allergy Clin Immunol. 2018 Aug;142(2):424-434.e10. doi: 10.1016/j.jaci.2017.08.041. Epub 2017 Dec 11. J Allergy Clin Immunol. 2018. PMID: 29241587 Free PMC article.
-
A humanized microbiota mouse model of ovalbumin-induced lung inflammation.Gut Microbes. 2016 Jul 3;7(4):342-352. doi: 10.1080/19490976.2016.1182293. Epub 2016 Apr 26. Gut Microbes. 2016. PMID: 27115049 Free PMC article.
-
Shifts in Lachnospira and Clostridium sp. in the 3-month stool microbiome are associated with preschool age asthma.Clin Sci (Lond). 2016 Dec 1;130(23):2199-2207. doi: 10.1042/CS20160349. Epub 2016 Sep 15. Clin Sci (Lond). 2016. PMID: 27634868
-
Microbial dysbiosis and childhood asthma development: Integrated role of the airway and gut microbiome, environmental exposures, and host metabolic and immune response.Front Immunol. 2022 Sep 30;13:1028209. doi: 10.3389/fimmu.2022.1028209. eCollection 2022. Front Immunol. 2022. PMID: 36248891 Free PMC article. Review.
Cited by
-
Epigenomics and Early Life Human Humoral Immunity: Novel Paradigms and Research Opportunities.Front Immunol. 2020 Sep 2;11:1766. doi: 10.3389/fimmu.2020.01766. eCollection 2020. Front Immunol. 2020. PMID: 32983086 Free PMC article. Review.
-
The dialogue between unconventional T cells and the microbiota.Mucosal Immunol. 2020 Nov;13(6):867-876. doi: 10.1038/s41385-020-0326-2. Epub 2020 Jul 23. Mucosal Immunol. 2020. PMID: 32704035 Review.
-
Gut microbiota and fecal metabolites in captive and wild North China leopard (Panthera pardus japonensis) by comparsion using 16 s rRNA gene sequencing and LC/MS-based metabolomics.BMC Vet Res. 2020 Sep 29;16(1):363. doi: 10.1186/s12917-020-02583-1. BMC Vet Res. 2020. PMID: 32993639 Free PMC article.
-
The Significance of the Enteric Microbiome on the Development of Childhood Disease: A Review of Prebiotic and Probiotic Therapies in Disorders of Childhood.Clin Med Insights Pediatr. 2016 Oct 9;10:91-107. doi: 10.4137/CMPed.S38338. eCollection 2016. Clin Med Insights Pediatr. 2016. PMID: 27774001 Free PMC article. Review.
-
Microbial diversity in individuals and their household contacts following typical antibiotic courses.Microbiome. 2016 Jul 30;4(1):39. doi: 10.1186/s40168-016-0187-9. Microbiome. 2016. PMID: 27473422 Free PMC article.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical