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Review
. 2016 Jan:22 Suppl 1:S34-6.
doi: 10.1016/j.parkreldis.2015.09.041. Epub 2015 Sep 25.

The phenotypic spectrum of progressive supranuclear palsy

G Respondek  1 , G U Höglinger  2
Affiliations
Review

The phenotypic spectrum of progressive supranuclear palsy

G Respondek et al. Parkinsonism Relat Disord. 2016 Jan.

Abstract

Traditionally, the clinical picture of progressive supranuclear palsy (PSP) was defined by early postural instability with falls, supranuclear vertical gaze palsy, symmetric akinesia and rigidity, frontal and subcortical dementia, and pseudobulbar palsy, leading to death after a mean disease duration of approximately six years. A definite diagnosis of PSP depends on neuropathological confirmation. In recent years, clinico-pathological studies have drawn attention to various "atypical" clinical manifestations of PSP. In these, a clinical diagnosis of PSP is delayed or never accomplished. Comprehensive understanding of the natural history of PSP is required to permit an early and accurate diagnosis. Based on current evidence, this review provides an update on the clinical spectrum of PSP.

Keywords: Phenotypes; Progressive supranuclear palsy PSP; Tauopathy.

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