Implications of the discovery of brain lymphatic pathways

doi:10.1016/S1474-4422(15)00221-5

Comment

. 2015 Oct;14(10):977-9.

doi: 10.1016/S1474-4422(15)00221-5.

Implications of the discovery of brain lymphatic pathways

Jeffrey J Iliff¹, Steven A Goldman², Maiken Nedergaard³

Affiliations

¹ Department of Anesthesiology and Perioperative Medicine, Knight Cardiovascular Institute, Oregon Health and Science University, Portland, OR, USA; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, USA.
² Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, USA; Center for Basic and Translational Neuroscience, University of Copenhagen, Copenhagen, Denmark.
³ Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, USA; Center for Basic and Translational Neuroscience, University of Copenhagen, Copenhagen, Denmark. Electronic address: nedergaard@urmc.rochester.edu.

PMID: 26376966
PMCID: PMC4655610
DOI: 10.1016/S1474-4422(15)00221-5

Comment

Implications of the discovery of brain lymphatic pathways

Jeffrey J Iliff et al. Lancet Neurol. 2015 Oct.

. 2015 Oct;14(10):977-9.

doi: 10.1016/S1474-4422(15)00221-5.

Authors

Jeffrey J Iliff¹, Steven A Goldman², Maiken Nedergaard³

Affiliations

¹ Department of Anesthesiology and Perioperative Medicine, Knight Cardiovascular Institute, Oregon Health and Science University, Portland, OR, USA; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, USA.
² Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, USA; Center for Basic and Translational Neuroscience, University of Copenhagen, Copenhagen, Denmark.
³ Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, USA; Center for Basic and Translational Neuroscience, University of Copenhagen, Copenhagen, Denmark. Electronic address: nedergaard@urmc.rochester.edu.

PMID: 26376966
PMCID: PMC4655610
DOI: 10.1016/S1474-4422(15)00221-5

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Structural and functional features of central nervous system lymphatic vessels.
Louveau A, Smirnov I, Keyes TJ, Eccles JD, Rouhani SJ, Peske JD, Derecki NC, Castle D, Mandell JW, Lee KS, Harris TH, Kipnis J. Louveau A, et al. Nature. 2015 Jul 16;523(7560):337-41. doi: 10.1038/nature14432. Epub 2015 Jun 1. Nature. 2015. PMID: 26030524 Free PMC article.
A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules.
Aspelund A, Antila S, Proulx ST, Karlsen TV, Karaman S, Detmar M, Wiig H, Alitalo K. Aspelund A, et al. J Exp Med. 2015 Jun 29;212(7):991-9. doi: 10.1084/jem.20142290. Epub 2015 Jun 15. J Exp Med. 2015. PMID: 26077718 Free PMC article.

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References

1. Davson H, Segal MB. Physiology of the CSF and blood-brain barriers. Boca Raton: CRC Press; 1996.
1. Cserr HF. Role of secretion and bulk flow of brain interstitial fluid in brain volume regulation. Annals of the New York Academy of Sciences. 1988;529:9–20. - PubMed
1. Weed LH. Studies on Cerebro-Spinal Fluid. No. III: The pathways of escape from the Subarachnoid Spaces with particular reference to the Arachnoid Villi. The Journal of medical research. 1914;31(1):51–91. - PMC - PubMed
1. Butler A. Correlated physiologic and structural studies of CSF absorption. In: Shapiro K, Marmarou A, Portnoy H, editors. Hydrocephalus. New York: Raven Press; 1984. pp. 41–57.
1. Louveau A, Smirnov I, Keyes TJ, et al. Structural and functional features of central nervous system lymphatic vessels. Nature. 2015 - PMC - PubMed

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[1] Davson H, Segal MB. Physiology of the CSF and blood-brain barriers. Boca Raton: CRC Press; 1996.

[2] Davson H, Segal MB. Physiology of the CSF and blood-brain barriers. Boca Raton: CRC Press; 1996.

[3] Cserr HF. Role of secretion and bulk flow of brain interstitial fluid in brain volume regulation. Annals of the New York Academy of Sciences. 1988;529:9–20. - PubMed

[4] Cserr HF. Role of secretion and bulk flow of brain interstitial fluid in brain volume regulation. Annals of the New York Academy of Sciences. 1988;529:9–20. - PubMed

[5] Weed LH. Studies on Cerebro-Spinal Fluid. No. III: The pathways of escape from the Subarachnoid Spaces with particular reference to the Arachnoid Villi. The Journal of medical research. 1914;31(1):51–91. - PMC - PubMed

[6] Weed LH. Studies on Cerebro-Spinal Fluid. No. III: The pathways of escape from the Subarachnoid Spaces with particular reference to the Arachnoid Villi. The Journal of medical research. 1914;31(1):51–91. - PMC - PubMed

[7] Butler A. Correlated physiologic and structural studies of CSF absorption. In: Shapiro K, Marmarou A, Portnoy H, editors. Hydrocephalus. New York: Raven Press; 1984. pp. 41–57.

[8] Butler A. Correlated physiologic and structural studies of CSF absorption. In: Shapiro K, Marmarou A, Portnoy H, editors. Hydrocephalus. New York: Raven Press; 1984. pp. 41–57.

[9] Louveau A, Smirnov I, Keyes TJ, et al. Structural and functional features of central nervous system lymphatic vessels. Nature. 2015 - PMC - PubMed

[10] Louveau A, Smirnov I, Keyes TJ, et al. Structural and functional features of central nervous system lymphatic vessels. Nature. 2015 - PMC - PubMed

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Implications of the discovery of brain lymphatic pathways

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