The impact of gut microbiota on brain and behaviour: implications for psychiatry
- PMID: 26372511
- DOI: 10.1097/MCO.0000000000000221
The impact of gut microbiota on brain and behaviour: implications for psychiatry
Abstract
Purpose of review: The gut microbiota has become a focus of research for those interested in the brain and behaviour. Here, we profile the gut microbiota in a variety of neuropsychiatric syndromes.
Recent findings: Multiple routes of communication between the gut and brain have been established and these include the vagus nerve, immune system, short chain fatty acids and tryptophan. Developmentally, those born by caesarean section have a distinctly different microbiota in early life to those born per vaginum. At the other extreme, individuals who age with considerable ill-heath tend to show narrowing in microbial diversity. Recently, the gut microbiota has been profiled in a variety of conditions including autism, major depression and Parkinson's disease. There is still debate as to whether or not these changes are core to the pathophysiology or merely epiphenomenal.
Summary: The current narrative suggests that certain neuropsychiatric disorders might be treated by targeting the microbiota either by microbiota transplantation, antibiotics or psychobiotics.
Similar articles
-
Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration.J Physiol. 2017 Jan 15;595(2):489-503. doi: 10.1113/JP273106. Epub 2016 Dec 4. J Physiol. 2017. PMID: 27641441 Free PMC article. Review.
-
The Microbiome-Gut-Brain Axis in Health and Disease.Gastroenterol Clin North Am. 2017 Mar;46(1):77-89. doi: 10.1016/j.gtc.2016.09.007. Epub 2017 Jan 4. Gastroenterol Clin North Am. 2017. PMID: 28164854 Review.
-
Microbiota-gut-brain signalling in Parkinson's disease: Implications for non-motor symptoms.Parkinsonism Relat Disord. 2016 Jun;27:1-8. doi: 10.1016/j.parkreldis.2016.03.012. Epub 2016 Mar 16. Parkinsonism Relat Disord. 2016. PMID: 27013171 Review.
-
Dysbiosis of gut microbiota and microbial metabolites in Parkinson's Disease.Ageing Res Rev. 2018 Aug;45:53-61. doi: 10.1016/j.arr.2018.04.004. Epub 2018 Apr 26. Ageing Res Rev. 2018. PMID: 29705121 Review.
-
Brain-gut-microbiota axis in Parkinson's disease.World J Gastroenterol. 2015 Oct 7;21(37):10609-20. doi: 10.3748/wjg.v21.i37.10609. World J Gastroenterol. 2015. PMID: 26457021 Free PMC article. Review.
Cited by
-
Hyperbaric oxygen improves depression-like behaviors in chronic stress model mice by remodeling gut microbiota and regulating host metabolism.CNS Neurosci Ther. 2023 Jan;29(1):239-255. doi: 10.1111/cns.13999. Epub 2022 Oct 19. CNS Neurosci Ther. 2023. PMID: 36261870 Free PMC article.
-
The Influence of Bifidobacterium bifidum and Bacteroides fragilis on Enteric Glial Cell-Derived Neurotrophic Factors and Inflammasome.Inflammation. 2020 Dec;43(6):2166-2177. doi: 10.1007/s10753-020-01284-z. Inflammation. 2020. PMID: 32638263
-
Polysaccharides From Abrus cantoniensis Hance Modulate Intestinal Microflora and Improve Intestinal Mucosal Barrier and Liver Oxidative Damage Induced by Heat Stress.Front Vet Sci. 2022 Apr 4;9:868433. doi: 10.3389/fvets.2022.868433. eCollection 2022. Front Vet Sci. 2022. PMID: 35445100 Free PMC article.
-
Mast Cells in Gut and Brain and Their Potential Role as an Emerging Therapeutic Target for Neural Diseases.Front Cell Neurosci. 2019 Jul 30;13:345. doi: 10.3389/fncel.2019.00345. eCollection 2019. Front Cell Neurosci. 2019. PMID: 31417365 Free PMC article. Review.
-
Resilience and immunity.Brain Behav Immun. 2018 Nov;74:28-42. doi: 10.1016/j.bbi.2018.08.010. Epub 2018 Aug 10. Brain Behav Immun. 2018. PMID: 30102966 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
