Multimodal imaging in Alzheimer's disease: validity and usefulness for early detection

doi:10.1016/S1474-4422(15)00093-9

Review

. 2015 Oct;14(10):1037-53.

doi: 10.1016/S1474-4422(15)00093-9. Epub 2015 Aug 26.

Multimodal imaging in Alzheimer's disease: validity and usefulness for early detection

Affiliations

¹ Department of Psychosomatic Medicine, University of Rostock, Rostock, Germany; DZNE, German Center for Neurodegenerative Diseases, Rostock, Germany. Electronic address: stefan.teipel@med.uni-rostock.de.
² Department of Nuclear Medicine, University of Cologne, Cologne, Germany.
³ Department of Psychosomatic Medicine, University of Rostock, Rostock, Germany; DZNE, German Center for Neurodegenerative Diseases, Rostock, Germany.
⁴ Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany.
⁵ Inserm-EPHE-Université de Caen, Caen cedex, France.
⁶ Department of Veterans Affairs Medical Center and Department of Radiology, University of California in San Francisco, San Francisco, CA, USA.
⁷ Olin Neuropsychiatry Research Center, Hartford Hospital and Institute of Living, Hartford, CT, USA; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
⁸ LENITEM Laboratory of Epidemiology, Neuroimaging, and Telemedicine-IRCCS Centro San Giovanni di Dio-FBF, Brescia, Italy; Sorbonne Universités, Université Pierre et Marie Curie, Paris 06, Institut de la Mémoire et de la Maladie d'Alzheimer and Institut du Cerveau et de la Moelle Epinière, UMR S 1127, Hôpital de la Pitié-Salpêtrière Paris and CATI Multicenter Neuroimaging Platform, France.
⁹ LENITEM Laboratory of Epidemiology, Neuroimaging, and Telemedicine-IRCCS Centro San Giovanni di Dio-FBF, Brescia, Italy; Memory Clinic and LANVIE-Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, Switzerland.
¹⁰ Institute for Community Medicine, University of Greifswald, Greifswald, Germany; DZNE, German Centre for Neurodegenerative Diseases, Greifswald, Germany.
¹¹ Dementia Research Innovation Group, Norwich Medical School, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, UK.
¹² Neuroimaging and Biotechnology Laboratory, Department of Radiology, University of Utah, Salt Lake City, UT, USA.
¹³ Department of Psychiatry, University Medical Center of Mainz, Mainz, Germany.

PMID: 26318837
DOI: 10.1016/S1474-4422(15)00093-9

Review

Multimodal imaging in Alzheimer's disease: validity and usefulness for early detection

Stefan Teipel et al. Lancet Neurol. 2015 Oct.

. 2015 Oct;14(10):1037-53.

doi: 10.1016/S1474-4422(15)00093-9. Epub 2015 Aug 26.

Authors

Affiliations

¹ Department of Psychosomatic Medicine, University of Rostock, Rostock, Germany; DZNE, German Center for Neurodegenerative Diseases, Rostock, Germany. Electronic address: stefan.teipel@med.uni-rostock.de.
² Department of Nuclear Medicine, University of Cologne, Cologne, Germany.
³ Department of Psychosomatic Medicine, University of Rostock, Rostock, Germany; DZNE, German Center for Neurodegenerative Diseases, Rostock, Germany.
⁴ Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany.
⁵ Inserm-EPHE-Université de Caen, Caen cedex, France.
⁶ Department of Veterans Affairs Medical Center and Department of Radiology, University of California in San Francisco, San Francisco, CA, USA.
⁷ Olin Neuropsychiatry Research Center, Hartford Hospital and Institute of Living, Hartford, CT, USA; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
⁸ LENITEM Laboratory of Epidemiology, Neuroimaging, and Telemedicine-IRCCS Centro San Giovanni di Dio-FBF, Brescia, Italy; Sorbonne Universités, Université Pierre et Marie Curie, Paris 06, Institut de la Mémoire et de la Maladie d'Alzheimer and Institut du Cerveau et de la Moelle Epinière, UMR S 1127, Hôpital de la Pitié-Salpêtrière Paris and CATI Multicenter Neuroimaging Platform, France.
⁹ LENITEM Laboratory of Epidemiology, Neuroimaging, and Telemedicine-IRCCS Centro San Giovanni di Dio-FBF, Brescia, Italy; Memory Clinic and LANVIE-Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, Switzerland.
¹⁰ Institute for Community Medicine, University of Greifswald, Greifswald, Germany; DZNE, German Centre for Neurodegenerative Diseases, Greifswald, Germany.
¹¹ Dementia Research Innovation Group, Norwich Medical School, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, UK.
¹² Neuroimaging and Biotechnology Laboratory, Department of Radiology, University of Utah, Salt Lake City, UT, USA.
¹³ Department of Psychiatry, University Medical Center of Mainz, Mainz, Germany.

PMID: 26318837
DOI: 10.1016/S1474-4422(15)00093-9

Abstract

Alzheimer's disease is a progressive neurodegenerative disease that typically manifests clinically as an isolated amnestic deficit that progresses to a characteristic dementia syndrome. Advances in neuroimaging research have enabled mapping of diverse molecular, functional, and structural aspects of Alzheimer's disease pathology in ever increasing temporal and regional detail. Accumulating evidence suggests that distinct types of imaging abnormalities related to Alzheimer's disease follow a consistent trajectory during pathogenesis of the disease, and that the first changes can be detected years before the disease manifests clinically. These findings have fuelled clinical interest in the use of specific imaging markers for Alzheimer's disease to predict future development of dementia in patients who are at risk. The potential clinical usefulness of single or multimodal imaging markers is being investigated in selected patient samples from clinical expert centres, but additional research is needed before these promising imaging markers can be successfully translated from research into clinical practice in routine care.

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Comment in

Integrated multimodal imaging in neurodegenerative disease.
Grossman M. Grossman M. Lancet Neurol. 2015 Oct;14(10):973-5. doi: 10.1016/S1474-4422(15)00182-9. Epub 2015 Aug 26. Lancet Neurol. 2015. PMID: 26318838 Free PMC article. No abstract available.

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Multimodal imaging in Alzheimer's disease: validity and usefulness for early detection

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Multimodal imaging in Alzheimer's disease: validity and usefulness for early detection

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