Priming of Human Resting NK Cells by Autologous M1 Macrophages via the Engagement of IL-1β, IFN-β, and IL-15 Pathways
- PMID: 26276870
- DOI: 10.4049/jimmunol.1500325
Priming of Human Resting NK Cells by Autologous M1 Macrophages via the Engagement of IL-1β, IFN-β, and IL-15 Pathways
Abstract
The cross talk between NK cells and macrophages is emerging as a major line of defense against microbial infections and tumors. This study reveals a complex network of soluble mediators and cell-to-cell interactions allowing human classically activated (M1) macrophages, but not resting (M0) or alternatively activated (M2) macrophages, to prime resting autologous NK cells. In this article, we show that M1 increase NK cell cytotoxicity by IL-23 and IFN-β-dependent upregulation of NKG2D, IL-1β-dependent upregulation of NKp44, and trans-presentation of IL-15. Moreover, both IFN-β-dependent cis-presentation of IL-15 on NK cells and engagement of the 2B4-CD48 pathway are used by M1 to trigger NK cell production of IFN-γ. The disclosure of these synergic cellular mechanisms regulating the M1-NK cell cross talk provides novel insights to better understand the role of innate immune responses in the physiopathology of tumor biology and microbial infections.
Copyright © 2015 by The American Association of Immunologists, Inc.
Similar articles
-
Reciprocal regulation of human natural killer cells and macrophages associated with distinct immune synapses.Blood. 2007 May 1;109(9):3776-85. doi: 10.1182/blood-2006-10-052977. Epub 2007 Jan 11. Blood. 2007. PMID: 17218381
-
Human M2 Macrophages Limit NK Cell Effector Functions through Secretion of TGF-β and Engagement of CD85j.J Immunol. 2018 Feb 1;200(3):1008-1015. doi: 10.4049/jimmunol.1700737. Epub 2017 Dec 27. J Immunol. 2018. PMID: 29282306
-
XLP1 inhibitory effect by 2B4 does not affect DNAM-1 and NKG2D activating pathways in NK cells.Eur J Immunol. 2014 May;44(5):1526-34. doi: 10.1002/eji.201344312. Epub 2014 Feb 27. Eur J Immunol. 2014. PMID: 24496997 Clinical Trial.
-
2B4 co-stimulation: NK cells and their control of adaptive immune responses.Mol Immunol. 2005 Feb;42(4):419-23. doi: 10.1016/j.molimm.2004.07.021. Mol Immunol. 2005. PMID: 15607793 Review.
-
Interleukin-15 as a potential regulator of the innate immune response.Braz J Med Biol Res. 1998 Jan;31(1):1-9. doi: 10.1590/s0100-879x1998000100001. Braz J Med Biol Res. 1998. PMID: 9686173 Review.
Cited by
-
Yeast β-glucan modulates macrophages and improves antitumor NK-cell responses in cancer.Clin Exp Immunol. 2023 Dec 11;214(1):50-60. doi: 10.1093/cei/uxad080. Clin Exp Immunol. 2023. PMID: 37455659 Free PMC article.
-
Modulation of liver regeneration via myeloid PTEN deficiency.Cell Death Dis. 2017 May 25;8(5):e2827. doi: 10.1038/cddis.2017.47. Cell Death Dis. 2017. PMID: 28542148 Free PMC article.
-
Anti-SIRPα antibodies as a potential new tool for cancer immunotherapy.JCI Insight. 2017 Jan 12;2(1):e89140. doi: 10.1172/jci.insight.89140. JCI Insight. 2017. PMID: 28097229 Free PMC article.
-
The yin-yang of the interaction between myelomonocytic cells and NK cells.Scand J Immunol. 2018 Sep;88(3):e12705. doi: 10.1111/sji.12705. Epub 2018 Aug 19. Scand J Immunol. 2018. PMID: 30048003 Free PMC article. Review.
-
Immuno-Diagnostic Interest in Monitoring CD16+CD56+ (Natural Killer) Cells and CD19+CD45+ (B Lymphocytes) in Individuals Newly Diagnosed with HIV in a Tertiary Care Center.J Clin Med. 2024 Feb 18;13(4):1154. doi: 10.3390/jcm13041154. J Clin Med. 2024. PMID: 38398466 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous
