Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Jul 17:6:363.
doi: 10.3389/fimmu.2015.00363. eCollection 2015.

Cross-Presentation of Cell-Associated Antigens by MHC Class I in Dendritic Cell Subsets

Enric Gutiérrez-Martínez  1 , Remi Planès  1 , Giorgio Anselmi  1 , Matthew Reynolds  1 , Shinelle Menezes  1 , Aimé Cézaire Adiko  2 , Loredana Saveanu  2 , Pierre Guermonprez  1
Affiliations
Review

Cross-Presentation of Cell-Associated Antigens by MHC Class I in Dendritic Cell Subsets

Enric Gutiérrez-Martínez et al. Front Immunol. .

Abstract

Dendritic cells (DCs) have the unique ability to pick up dead cells carrying antigens in tissue and migrate to the lymph nodes where they can cross-present cell-associated antigens by MHC class I to CD8(+) T cells. There is strong in vivo evidence that the mouse XCR1(+) DCs subset acts as a key player in this process. The intracellular processes underlying cross-presentation remain controversial and several pathways have been proposed. Indeed, a wide number of studies have addressed the cellular process of cross-presentation in vitro using a variety of sources of antigen and antigen-presenting cells. Here, we review the in vivo and in vitro evidence supporting the current mechanistic models and disscuss their physiological relevance to the cross-presentation of cell-associated antigens by DCs subsets.

Keywords: MHC class I; antigen processing; cross-presentation; cross-priming; dendritic cells; phagocytosis.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Bevan MJ. Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay. J Exp Med (1976) 143(5):1283–8.10.1084/jem.143.5.1283 - DOI - PMC - PubMed
    1. Bevan MJ. Minor H antigens introduced on H-2 different stimulating cells cross-react at the cytotoxic T cell level during in vivo priming. J Immunol (1976) 117(6):2233–8. - PubMed
    1. Carbone FR, Bevan MJ. Class I-restricted processing and presentation of exogenous cell-associated antigen in vivo. J Exp Med (1990) 171(2):377–87.10.1084/jem.171.2.377 - DOI - PMC - PubMed
    1. Gooding LR, Edwards CB. H-2 antigen requirements in the in vitro induction of SV40-specific cytotoxic T lymphocytes. J Immunol (1980) 124(3):1258–62. - PubMed
    1. Huang AY, Golumbek P, Ahmadzadeh M, Jaffee E, Pardoll D, Levitsky H. Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens. Science (1994) 264(5161):961–5.10.1126/science.7513904 - DOI - PubMed