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Review
. 2015 Aug;31(4):382-94.
doi: 10.1007/s12264-015-1528-y. Epub 2015 Jun 15.

Autophagic activity in neuronal cell death

Robert W Button  1 , Shouqing Luo, David C Rubinsztein
Affiliations
Review

Autophagic activity in neuronal cell death

Robert W Button et al. Neurosci Bull. 2015 Aug.

Abstract

As post-mitotic cells with great energy demands, neurons depend upon the homeostatic and waste-recycling functions provided by autophagy. In addition, autophagy also promotes survival during periods of harsh stress and targets aggregate-prone proteins associated with neurodegeneration for degradation. Despite this, autophagy has also been controversially described as a mechanism of programmed cell death. Instances of autophagic cell death are typically associated with elevated numbers of cytoplasmic autophagosomes, which have been assumed to lead to excessive degradation of cellular components. Due to the high activity and reliance on autophagy in neurons, these cells may be particularly susceptible to autophagic death. In this review, we summarize and assess current evidence in support of autophagic cell death in neurons, as well as how the dysregulation of autophagy commonly seen in neurodegeneration can contribute to neuron loss. From here, we discuss potential treatment strategies relevant to such cell-death pathways.

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References

    1. Feng Y, He D, Yao Z, Klionsky DJ. The machinery of macroautophagy. Cell Res. 2014;24:24–41. - PMC - PubMed
    1. Shibutani ST, Yoshimori T. A current perspective of autophagosome biogenesis. Cell Res. 2014;24:58–68. - PMC - PubMed
    1. Yang Z, Klionsky DJ. Eaten alive: a history of macroautophagy. Nat Cell Biol. 2010;12:814–822. - PMC - PubMed
    1. Rabinowitz JD, White E. Autophagy and metabolism. Science. 2010;330:1344–1348. - PMC - PubMed
    1. Russell RC, Yuan HX, Guan KL. Autophagy regulation by nutrient signaling. Cell Res. 2014;24:42–57. - PMC - PubMed

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