Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2017 Mar;27(1):71-79.
doi: 10.1007/s00062-015-0398-7. Epub 2015 May 19.

Process of the Functional Reorganization of the Cortical Centers for Movement in GBM Patients: fMRI Study

A Majos  1 , B Bryszewski  2 , K N Kośla  3 , L Pfaifer  1 , D Jaskólski  2 , L Stefańczyk  1
Affiliations
Clinical Trial

Process of the Functional Reorganization of the Cortical Centers for Movement in GBM Patients: fMRI Study

A Majos et al. Clin Neuroradiol. 2017 Mar.

Abstract

Purpose: The aim of this study was to verify whether the functional reorganization of motor cortex is associated with the increase in the size of WHO type IV glioma lesion, that is, disease duration and development, and whether surgical treatment has an impact on cerebral plasticity.

Methods: The study included 16 patients with primary tumors of the brain located at the region of central sulcus. The clinical status of patients and tumor volume was determined. Functional magnetic resonance imaging examinations were performed before and 3 months after operation.

Results: The activity of all cortical centers, both contralateral and ipsilateral, was observed in a group of small as well as large tumors. The intensity of activation and the number of activated clusters of small tumors were almost always higher as compared with the large tumors. The frequency of the activity of contralateral areas was similar during the first and the second examination. In the case of ipsilateral centers, the frequency of activation during the second examination was lower. Mean values of t-statistics during the first examination were higher than during the second examination. Supplementary motor area (SMAa) was the only center for which the mean values of activation intensity remained similar.

Conclusions: SMAa seems to play the most important role in the processes of motor cortex plasticity in high-grade glioma patients. Surgery seems not having a significant influence on the pattern of functional reorganization of the cortical centers for movement. Identification of the individual patterns of the reorganization of motor centers plays an important role in clinical practice.

Keywords: Brain plasticity; Brain tumor; Movement centers; fMRI.

PubMed Disclaimer

Conflict of interest statement

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Figures

Fig. 1
Fig. 1
Patient JP. fMRI examinations, activation in primary motor area, (a) before, (b) after operation
Fig. 2
Fig. 2
Patient MR. fMRI examinations, (a) activation in primary motor area and supplementary motor area before operation, (b) in primary motor area after operation
Fig. 3
Fig. 3
Values of t-statistics in analyzed motor areas in fMRI examinations. I—Before operation. II—After operation. M1a contralateral primary motor area, M1u ipsilateral primary motor cortex, PMAa contralateral premotor area, SMAa supplementary motor area
Fig. 4
Fig. 4
Number of clusters activated in analyzed motor areas during in fMRI examinations. I—Before operation. II—After operation. M1a contralateral primary motor area, M1u ipsilateral primary motor cortex, PMAa contralateral premotor area, SMAa supplementary motor area
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Rossini PM, Pauri F. Neuromagnetic integrated methods tracking human brain mechanisms of sensorimotor areas ‘plastic’ reorganisation. Brain Res Brain Res Rev. 2007;33:131–54. doi: 10.1016/S0169-328X(00)00090-5. - DOI - PubMed
    1. Xerri C. Plasticity of cortical maps: multiple triggers for adaptive reorganization following brain damage and spinal cord injury. Neuroscientist. 2012;18:133–48. doi: 10.1177/1073858410397894. - DOI - PubMed
    1. Wengenroth M, Blatow M, Guenther J, Akbar M, Tronnier VM, Stippich C. Diagnostic benefits of presurgical fMRI in patients with brain tumours in the primary sensorimotor cortex. Eur Radiol. 2011;21:1517–25. doi: 10.1007/s00330-011-2067-9. - DOI - PMC - PubMed
    1. Peck KK, Bradbury MS, Hou BL, Brennan NP, Holodny AI. The role of the supplementary motor area (SMA) in the execution of primary motor activities in brain tumor patients: functional MRI detection of time-resolved differences in the hemodynamic response. Med Sci Monit. 2009;15:55–62. - PubMed
    1. Borges AR, Lopez-Larrubia P, Marques JB, Cerdan SG. MR imaging features of high-grade gliomas in murine models: how they compare with human disease, reflect tumor biology, and play a role in preclinical trials. Am J Neuroradiol. 2012;33:24–36. doi: 10.3174/ajnr.A2959. - DOI - PMC - PubMed

Publication types