Evidence-based guidelines for treating depressive disorders with antidepressants: A revision of the 2008 British Association for Psychopharmacology guidelines

doi:10.1177/0269881115581093

Practice Guideline

. 2015 May;29(5):459-525.

doi: 10.1177/0269881115581093. Epub 2015 May 12.

Evidence-based guidelines for treating depressive disorders with antidepressants: A revision of the 2008 British Association for Psychopharmacology guidelines

Anthony Cleare¹, C M Pariante², A H Young³, I M Anderson⁴, D Christmas⁵, P J Cowen⁶, C Dickens⁷, I N Ferrier⁸, J Geddes⁹, S Gilbody¹⁰, P M Haddad¹¹, C Katona¹², G Lewis¹², A Malizia¹³, R H McAllister-Williams¹⁴, P Ramchandani¹⁵, J Scott¹⁶, D Taylor¹⁷, R Uher¹⁸; Members of the Consensus Meeting

Affiliations

¹ Professor of Psychopharmacology & Affective Disorders, King's College London, Institute of Psychiatry, Psychology and Neuroscience, Centre for Affective Disorders, London, UK anthony.cleare@kcl.ac.uk.
² Professor of Biological Psychiatry, King's College London, Institute of Psychiatry, Psychology and Neuroscience, Centre for Affective Disorders, London, UK.
³ Professor of Psychiatry and Chair of Mood Disorders, King's College London, Institute of Psychiatry, Psychology and Neuroscience, Centre for Affective Disorders, London, UK.
⁴ Professor and Honorary Consultant Psychiatrist, University of Manchester Department of Psychiatry, University of Manchester, Manchester, UK.
⁵ Consultant Psychiatrist, Advanced Interventions Service, Ninewells Hospital & Medical School, Dundee, UK.
⁶ Professor of Psychopharmacology, Psychopharmacology Research Unit, Neurosciences Building, University Department of Psychiatry, Warneford Hospital, Oxford, UK.
⁷ Professor of Psychological Medicine, University of Exeter Medical School and Devon Partnership Trust, Exeter, UK.
⁸ Professor of Psychiatry, Honorary Consultant Psychiatrist, School of Neurology, Neurobiology & Psychiatry, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
⁹ Head, Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK.
¹⁰ Director of the Mental Health and Addictions Research Group (MHARG), The Hull York Medical School, Department of Health Sciences, University of York, York, UK.
¹¹ Consultant Psychiatrist, Cromwell House, Greater Manchester West Mental Health NHS Foundation Trust, Salford, UK.
¹² Division of Psychiatry, University College London, London, UK.
¹³ Consultant in Neuropsychopharmacology and Neuromodulation, North Bristol NHS Trust, Rosa Burden Centre, Southmead Hospital, Bristol, UK.
¹⁴ Reader in Clinical Psychopharmacology, Institute of Neuroscience, Newcastle University, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
¹⁵ Reader in Child and Adolescent Psychiatry, Centre for Mental Health, Imperial College London, London, UK.
¹⁶ Professor of Psychological Medicine, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.
¹⁷ Professor of Psychopharmacology, King's College London, London, UK.
¹⁸ Associate Professor, Canada Research Chair in Early Interventions, Dalhousie University, Department of Psychiatry, Halifax, NS, Canada.

PMID: 25969470
DOI: 10.1177/0269881115581093

Practice Guideline

Evidence-based guidelines for treating depressive disorders with antidepressants: A revision of the 2008 British Association for Psychopharmacology guidelines

Anthony Cleare et al. J Psychopharmacol. 2015 May.

. 2015 May;29(5):459-525.

doi: 10.1177/0269881115581093. Epub 2015 May 12.

Authors

Affiliations

¹ Professor of Psychopharmacology & Affective Disorders, King's College London, Institute of Psychiatry, Psychology and Neuroscience, Centre for Affective Disorders, London, UK anthony.cleare@kcl.ac.uk.
² Professor of Biological Psychiatry, King's College London, Institute of Psychiatry, Psychology and Neuroscience, Centre for Affective Disorders, London, UK.
³ Professor of Psychiatry and Chair of Mood Disorders, King's College London, Institute of Psychiatry, Psychology and Neuroscience, Centre for Affective Disorders, London, UK.
⁴ Professor and Honorary Consultant Psychiatrist, University of Manchester Department of Psychiatry, University of Manchester, Manchester, UK.
⁵ Consultant Psychiatrist, Advanced Interventions Service, Ninewells Hospital & Medical School, Dundee, UK.
⁶ Professor of Psychopharmacology, Psychopharmacology Research Unit, Neurosciences Building, University Department of Psychiatry, Warneford Hospital, Oxford, UK.
⁷ Professor of Psychological Medicine, University of Exeter Medical School and Devon Partnership Trust, Exeter, UK.
⁸ Professor of Psychiatry, Honorary Consultant Psychiatrist, School of Neurology, Neurobiology & Psychiatry, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
⁹ Head, Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK.
¹⁰ Director of the Mental Health and Addictions Research Group (MHARG), The Hull York Medical School, Department of Health Sciences, University of York, York, UK.
¹¹ Consultant Psychiatrist, Cromwell House, Greater Manchester West Mental Health NHS Foundation Trust, Salford, UK.
¹² Division of Psychiatry, University College London, London, UK.
¹³ Consultant in Neuropsychopharmacology and Neuromodulation, North Bristol NHS Trust, Rosa Burden Centre, Southmead Hospital, Bristol, UK.
¹⁴ Reader in Clinical Psychopharmacology, Institute of Neuroscience, Newcastle University, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
¹⁵ Reader in Child and Adolescent Psychiatry, Centre for Mental Health, Imperial College London, London, UK.
¹⁶ Professor of Psychological Medicine, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.
¹⁷ Professor of Psychopharmacology, King's College London, London, UK.
¹⁸ Associate Professor, Canada Research Chair in Early Interventions, Dalhousie University, Department of Psychiatry, Halifax, NS, Canada.

PMID: 25969470
DOI: 10.1177/0269881115581093

Abstract

A revision of the 2008 British Association for Psychopharmacology evidence-based guidelines for treating depressive disorders with antidepressants was undertaken in order to incorporate new evidence and to update the recommendations where appropriate. A consensus meeting involving experts in depressive disorders and their management was held in September 2012. Key areas in treating depression were reviewed and the strength of evidence and clinical implications were considered. The guidelines were then revised after extensive feedback from participants and interested parties. A literature review is provided which identifies the quality of evidence upon which the recommendations are made. These guidelines cover the nature and detection of depressive disorders, acute treatment with antidepressant drugs, choice of drug versus alternative treatment, practical issues in prescribing and management, next-step treatment, relapse prevention, treatment of relapse and stopping treatment. Significant changes since the last guidelines were published in 2008 include the availability of new antidepressant treatment options, improved evidence supporting certain augmentation strategies (drug and non-drug), management of potential long-term side effects, updated guidance for prescribing in elderly and adolescent populations and updated guidance for optimal prescribing. Suggestions for future research priorities are also made.

Keywords: Antidepressants; depression; depressive disorder; evidence-based guidelines; treatment.

PubMed Disclaimer

Cited by

Implementation of a care manager organisation and its association with antidepressant medication patterns: a register-based study of primary care centres in Sweden.
Sandheimer C, Björkelund C, Hensing G, Mehlig K, Hedenrud T. Sandheimer C, et al. BMJ Open. 2021 Mar 5;11(3):e044959. doi: 10.1136/bmjopen-2020-044959. BMJ Open. 2021. PMID: 33674375 Free PMC article.
Neurobiological and pharmacological arguments for customization of cognitive behavioral psychotherapy in the treatment of major depressive disorder.
Ristea S, Schenker RA, Stovicek PO, Pîrlog MC, Marinescu D. Ristea S, et al. Rom J Morphol Embryol. 2021 Jul-Sep;62(3):807-817. doi: 10.47162/RJME.62.3.19. Rom J Morphol Embryol. 2021. PMID: 35263410 Free PMC article.
Analysis of Time-Course, Dose-Effect, and Influencing Factors of Antidepressants in the Treatment of Acute Adult Patients With Major Depression.
Cheng Q, Huang J, Xu L, Li Y, Li H, Shen Y, Zheng Q, Li L. Cheng Q, et al. Int J Neuropsychopharmacol. 2020 Feb 1;23(2):76-87. doi: 10.1093/ijnp/pyz062. Int J Neuropsychopharmacol. 2020. PMID: 31774497 Free PMC article.
Results from a long-term open-label extension study of adjunctive buprenorphine/samidorphan combination in patients with major depressive disorder.
Thase ME, Stanford AD, Memisoglu A, Martin W, Claxton A, Bodkin JA, Trivedi MH, Fava M, Yu M, Pathak S. Thase ME, et al. Neuropsychopharmacology. 2019 Dec;44(13):2268-2276. doi: 10.1038/s41386-019-0451-3. Epub 2019 Jun 29. Neuropsychopharmacology. 2019. PMID: 31254971 Free PMC article. Clinical Trial.
Body mass index and inflammation in depression and treatment-resistant depression: a Mendelian randomisation study.
Karageorgiou V, Casanova F, O'Loughlin J, Green H, McKinley TJ, Bowden J, Tyrrell J. Karageorgiou V, et al. BMC Med. 2023 Sep 14;21(1):355. doi: 10.1186/s12916-023-03001-7. BMC Med. 2023. PMID: 37710313 Free PMC article.

See all "Cited by" articles

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions

Grants and funding

G108/603/MRC_/Medical Research Council/United Kingdom

LinkOut - more resources

Full Text Sources
- Atypon
- Ovid Technologies, Inc.
Other Literature Sources
- The Lens - Patent Citations Database
Medical
- MedlinePlus Health Information

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Evidence-based guidelines for treating depressive disorders with antidepressants: A revision of the 2008 British Association for Psychopharmacology guidelines

Affiliations

Evidence-based guidelines for treating depressive disorders with antidepressants: A revision of the 2008 British Association for Psychopharmacology guidelines

Authors

Affiliations

Abstract

Similar articles

Cited by

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Abstract

Similar articles

Cited by

Publication types

MeSH terms

Substances

Related information

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical