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. 2015:2015:141598.
doi: 10.1155/2015/141598. Epub 2015 Apr 14.

Ocular rigidity and outflow facility in nonproliferative diabetic retinopathy

Theonitsa Panagiotoglou  1 , Miltiadis Tsilimbaris  2 , Harilaos Ginis  3 , Nikos Karyotakis  3 , Vaggelis Georgiou  4 , Pavlos Koutentakis  5 , Ioannis Pallikaris  2
Affiliations

Ocular rigidity and outflow facility in nonproliferative diabetic retinopathy

Theonitsa Panagiotoglou et al. J Diabetes Res. 2015.

Abstract

Purpose: To compare ocular rigidity (OR) and outflow facility (C) in patients with nonproliferative diabetic retinopathy (NPDR) and control subjects.

Methods: Twenty-four patients with NPDR (NPDR group) and 24 controls (control group) undergoing cataract surgery were enrolled. NPDR group was further divided into patients with mild NPDR (NPDR1-group) and patients with moderate and/or severe NPDR (NPDR2-group). After cannulation of the anterior chamber, a computer-controlled device was used to infuse saline and increase the intraocular pressure (IOP) in a stepping procedure from 15 to 40 mmHg. Ocular rigidity and outflow facility coefficients were estimated from IOP and volume recordings.

Results: Ocular rigidity was 0.0205 μL(-1) in NPDR group and 0.0202 μL(-1) in control group (P = 0.942). In NPDR1-group, OR was 0.017 μL(-1) and in NPDR2-group it was 0.025 μL(-1) (P = 0.192). Outflow facility was 0.120 μL/min/mmHg in NPDR-group compared to 0.153 μL/min/mmHg in the control group at an IOP of 35 mmHg (P = 0.151). There was no difference in C between NPDR1-group and NPDR2-group (P = 0.709).

Conclusions: No statistically significant differences in ocular rigidity and outflow facility could be documented between diabetic patients and controls. No difference in OR and C was detected between mild NPDR and severe NPDR.

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Figures

Figure 1
Figure 1
Setup of the system for the intraoperative measurement of ocular rigidity and outflow facility.
Figure 2
Figure 2
Ocular rigidity (μL−1). Boxplots of mean ocular rigidity coefficient in NPDR group (n = 24) and control group (n = 24).
Figure 3
Figure 3
Outflow facility (μL/min/mmHg). Boxplots of mean outflow facility coefficient in NPDR group (n = 24) and control group (n = 24).
See this image and copyright information in PMC

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