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. 2015 Apr;73(4):571-5.

[Sex hormones and metabolic function]

[Article in Japanese]
Toshihiko Yanase, Makito Tanabe, Takashi Nomiyama
  • PMID: 25936143

[Sex hormones and metabolic function]

[Article in Japanese]
Toshihiko Yanase et al. Nihon Rinsho. 2015 Apr.

Abstract

The biological actions of testosterone(T) and estrogens(E) are mediated via androgen receptor(AR) and estrogen receptor(ER), respectively. Testosterone also exerts its effect by conversion to estrogens by aromatase in peripheral tissues. Recently, from the detailed analysis of the phenotype of human or mouse mutant of AR, ER and aromatase, T-AR, E-ERs are protective against metabolic syndrome(MetS) and diabetes mellitus(DM). Both sex steroids are suggested to potentiate leptin signaling as a central mechanism and to suppress lipid synthesis and promote lipolysis as peripheral mechanism. Thus, the insufficiency of the amount or action of these sex steroids causes obesity and insulin resistance. Age-associated decrease of sex steroids is an important background for the onset of visceral obesity and life-related diseases.

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