Oxidative stress, insulin resistance, dyslipidemia and type 2 diabetes mellitus
- PMID: 25897356
- PMCID: PMC4398902
- DOI: 10.4239/wjd.v6.i3.456
Oxidative stress, insulin resistance, dyslipidemia and type 2 diabetes mellitus
Abstract
Oxidative stress is increased in metabolic syndrome and type 2 diabetes mellitus (T2DM) and this appears to underlie the development of cardiovascular disease, T2DM and diabetic complications. Increased oxidative stress appears to be a deleterious factor leading to insulin resistance, dyslipidemia, β-cell dysfunction, impaired glucose tolerance and ultimately leading to T2DM. Chronic oxidative stress, hyperglycemia and dyslipidemia are particularly dangerous for β-cells from lowest levels of antioxidant, have high oxidative energy requirements, decrease the gene expression of key β-cell genes and induce cell death. If β-cell functioning is impaired, it results in an under production of insulin, impairs glucose stimulated insulin secretion, fasting hyperglycemia and eventually the development of T2DM.
Keywords: Dyslipidemia; Insulin resistance; Oxidative stress; Type 2 diabetes mellitus.
Figures
Similar articles
-
Administration of Tonsil-Derived Mesenchymal Stem Cells Improves Glucose Tolerance in High Fat Diet-Induced Diabetic Mice via Insulin-Like Growth Factor-Binding Protein 5-Mediated Endoplasmic Reticulum Stress Modulation.Cells. 2019 Apr 23;8(4):368. doi: 10.3390/cells8040368. Cells. 2019. PMID: 31018536 Free PMC article.
-
[Role of insulin resistance and β cell function in the development of newly diagnosed type 2 diabetes].Wei Sheng Yan Jiu. 2015 Nov;44(6):881-6. Wei Sheng Yan Jiu. 2015. PMID: 26738376 Chinese.
-
Role of oxidative stress in pancreatic beta-cell dysfunction.Ann N Y Acad Sci. 2004 Apr;1011:168-76. doi: 10.1007/978-3-662-41088-2_17. Ann N Y Acad Sci. 2004. PMID: 15126294
-
Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited.Arterioscler Thromb Vasc Biol. 2004 May;24(5):816-23. doi: 10.1161/01.ATV.0000122852.22604.78. Epub 2004 Feb 19. Arterioscler Thromb Vasc Biol. 2004. PMID: 14976002 Review.
-
Advanced glycation end products and oxidative stress in type 2 diabetes mellitus.Biomolecules. 2015 Mar 16;5(1):194-222. doi: 10.3390/biom5010194. Biomolecules. 2015. PMID: 25786107 Free PMC article. Review.
Cited by
-
Association of triglyceride glucose-body mass index with Alzheimer's disease pathology, cognition and brain structure in non-demented people.Sci Rep. 2024 Jul 12;14(1):16097. doi: 10.1038/s41598-024-67052-3. Sci Rep. 2024. PMID: 38997334 Free PMC article.
-
Chemical Profile of Launaea nudicaulis Ethanolic Extract and Its Antidiabetic Effect in Streptozotocin-Induced Rats.Molecules. 2021 Feb 13;26(4):1000. doi: 10.3390/molecules26041000. Molecules. 2021. PMID: 33668635 Free PMC article.
-
Hypomagnesemia and Cardiovascular Risk in Type 2 Diabetes.Endocr Rev. 2023 May 8;44(3):357-378. doi: 10.1210/endrev/bnac028. Endocr Rev. 2023. PMID: 36346820 Free PMC article.
-
Effect of sodium tungstate on visual evoked potentials in diabetic rats.Int J Ophthalmol. 2016 May 18;9(5):677-81. doi: 10.18240/ijo.2016.05.06. eCollection 2016. Int J Ophthalmol. 2016. PMID: 27275420 Free PMC article.
-
Modulatory influence of Parkia biglobosa protein isolate on testosterone and biomarkers of oxidative stress in brain and testes of streptozotocin-induced diabetic male rats.Int J Physiol Pathophysiol Pharmacol. 2016 Sep 30;8(3):78-86. eCollection 2016. Int J Physiol Pathophysiol Pharmacol. 2016. PMID: 27785334 Free PMC article.
References
-
- Cossarizza A, Ferraresi R, Troiano L, Roat E, Gibellini L, Bertoncelli L, Nasi M, Pinti M. Simultaneous analysis of reactive oxygen species and reduced glutathione content in living cells by polychromatic flow cytometry. Nat Protoc. 2009;4:1790–1797. - PubMed
-
- Sies H. Oxidative stress: oxidants and antioxidants. Exp Physiol. 1997;82:291–295. - PubMed
-
- Freeman BA, Crapo JD. Biology of disease: free radicals and tissue injury. Lab Invest. 1982;47:412–426. - PubMed
Publication types
LinkOut - more resources
Full Text Sources
Other Literature Sources