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. 2015 May 29;348(6238):995-1001.
doi: 10.1126/science.aaa7516. Epub 2015 Apr 16.

RETRACTED: T cell metabolism. The protein LEM promotes CD8⁺ T cell immunity through effects on mitochondrial respiration

Isobel Okoye  1 , Lihui Wang  1 , Katharina Pallmer  2 , Kirsten Richter  2 , Takahuru Ichimura  3 , Robert Haas  4 , Josh Crouse  2 , Onjee Choi  1 , Dean Heathcote  1 , Elena Lovo  1 , Claudio Mauro  4 , Reza Abdi  3 , Annette Oxenius  2 , Sophie Rutschmann  1 , Philip G Ashton-Rickardt  5
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Free article

RETRACTED: T cell metabolism. The protein LEM promotes CD8⁺ T cell immunity through effects on mitochondrial respiration

Isobel Okoye et al. Science. .
Free article

Retraction in

  • Retraction.
    Sills J, Berg J. Sills J, et al. Science. 2016 Dec 16;354(6318):1385. doi: 10.1126/science.aal5242. Science. 2016. PMID: 27980177 No abstract available.

Expression of concern in

  • Editorial expression of concern.
    McNutt M. McNutt M. Science. 2015 Dec 18;350(6267):1482. doi: 10.1126/science.aae0548. Epub 2015 Dec 10. Science. 2015. PMID: 26657284 No abstract available.

Abstract

Protective CD8(+) T cell-mediated immunity requires a massive expansion in cell number and the development of long-lived memory cells. Using forward genetics in mice, we identified an orphan protein named lymphocyte expansion molecule (LEM) that promoted antigen-dependent CD8(+) T cell proliferation, effector function, and memory cell generation in response to infection with lymphocytic choriomeningitis virus. Generation of LEM-deficient mice confirmed these results. Through interaction with CR6 interacting factor (CRIF1), LEM controlled the levels of oxidative phosphorylation (OXPHOS) complexes and respiration, resulting in the production of pro-proliferative mitochondrial reactive oxygen species (mROS). LEM provides a link between immune activation and the expansion of protective CD8(+) T cells driven by OXPHOS and represents a pathway for the restoration of long-term protective immunity based on metabolically modified cytotoxic CD8(+) T cells.

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