Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Apr;29(2):377-94, x-xi.
doi: 10.1016/j.hoc.2014.11.003.

Therapeutic opportunities in the intrinsic subtypes of muscle-invasive bladder cancer

David J McConkey  1 , Woonyoung Choi  2 , Andrea Ochoa  2 , Arlene Siefker-Radtke  3 , Bogdan Czerniak  4 , Colin P N Dinney  5
Affiliations
Review

Therapeutic opportunities in the intrinsic subtypes of muscle-invasive bladder cancer

David J McConkey et al. Hematol Oncol Clin North Am. 2015 Apr.

Abstract

Recent studies revealed that muscle-invasive bladder cancers segregate into intrinsic basal and luminal subtypes that are similar to those described for breast cancer. Each subtype is enriched with potentially clinically actionable genomic alterations and epigenetic signatures; there are associations between tumor subtype and sensitivity to conventional cisplatin-based chemotherapy. The authors review biological and clinical characteristics of the intrinsic subtypes and describe their implications for the development of conventional and targeted agents. The role that tumor plasticity seems to play in basal and luminal bladder cancer biology and its potential effects on the development of therapeutic resistance is also discussed.

Keywords: Basal and luminal; Neoadjuvant chemotherapy; Urothelial cancer.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

MeSH terms

Substances