Synergism between lysophosphatidylserine and the phorbol ester tetradecanoylphorbolacetate in rat mast cells
- PMID: 2580209
- DOI: 10.1016/0024-3205(85)90383-2
Synergism between lysophosphatidylserine and the phorbol ester tetradecanoylphorbolacetate in rat mast cells
Abstract
In rat peritoneal mast cells tetradecanoylphorbolacetate (TPA) induced a non cytotoxic histamine release in the absence of extracellular calcium. The addition of calcium prevented the TPA effect but micromolar concentrations of lysophosphatidylserine (lysoPS) converted the calcium-induced inhibition into a stimulation. Other lysophospholipids were inactive. In agreement with a mutual influence between lysoPS and TPA, minimal TPA concentrations enhanced the calcium-dependent histamine release induced by lysoPS in the presence of nerve-growth factor. It is proposed that the calcium-dependent pathway promoted by lysoPS and the activation of protein kinase C by TPA act synergically to induce histamine release from mast cells.
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