Potential utility of liposome bupivacaine in orthopedic surgery
- PMID: 25750943
Potential utility of liposome bupivacaine in orthopedic surgery
Abstract
Management of postsurgical analgesia is an important consideration in orthopedic procedures, including joint arthroplasty. Inadequate postsurgical analgesia is associated with increased hospital length of stay, delayed ambulation, and reduced exercise capacity. In this article, we review the potential contribution of a prolonged-release liposomal formulation of bupivacaine as part of a multimodal analgesic regimen after orthopedic surgery. Controlled studies across multiple surgical settings have demonstrated that, compared with placebo and bupivacaine HCl, liposome bupivacaine in a single administration provides postsurgical analgesia for up to 72 hours, delays use of rescue medication, and reduces postsurgical opioid consumption. Liposome bupivacaine has been well tolerated in clinical studies and has had a low rate of treatment-related adverse events. To date, there has been no signal of cardiac toxicity, chondrolysis, or delayed wound healing associated with liposome bupivacaine.
Similar articles
-
Evolving Role of Local Anesthetics in Managing Postsurgical Analgesia.Clin Ther. 2015 Jun 1;37(6):1354-71. doi: 10.1016/j.clinthera.2015.03.017. Epub 2015 Apr 10. Clin Ther. 2015. PMID: 25866297 Review.
-
Impact of local administration of liposome bupivacaine for postsurgical analgesia on wound healing: a review of data from ten prospective, controlled clinical studies.Clin Ther. 2013 Mar;35(3):312-320.e5. doi: 10.1016/j.clinthera.2013.02.005. Epub 2013 Mar 1. Clin Ther. 2013. PMID: 23453403 Review.
-
Liposomal bupivacaine: an innovative nonopioid local analgesic for the management of postsurgical pain.Pharmacotherapy. 2012 Sep;32(9 Suppl):19S-26S. doi: 10.1002/j.1875-9114.2012.01183.x. Pharmacotherapy. 2012. PMID: 22956491
-
Evaluating therapeutic benefit in postsurgical analgesia requires global assessment: an example from liposome bupivacaine in hemorrhoidectomy.Hosp Pract (1995). 2012 Feb;40(1):160-5. doi: 10.3810/hp.2012.02.956. Hosp Pract (1995). 2012. PMID: 22406891
-
Bupivacaine liposome injectable suspension: a new approach to postsurgical pain.Drugs Today (Barc). 2013 Aug;49(8):475-82. doi: 10.1358/dot.2013.49.8.2006992. Drugs Today (Barc). 2013. PMID: 23977664
Cited by
-
Novel CO2-encapsulated Pluronic F127 hydrogel for the treatment of Achilles tendon injury.Sci Rep. 2023 Dec 11;13(1):21895. doi: 10.1038/s41598-023-49339-z. Sci Rep. 2023. PMID: 38081952 Free PMC article.
-
The use of extended release bupivacaine with transversus abdominis plane and subcostal anterior quadratus lumborum catheters: A retrospective analysis of a novel technique.J Anaesthesiol Clin Pharmacol. 2020 Jan-Mar;36(1):110-114. doi: 10.4103/joacp.JOACP_358_18. Epub 2020 Feb 18. J Anaesthesiol Clin Pharmacol. 2020. PMID: 32174670 Free PMC article.
-
Placenta-specific drug delivery by trophoblast-targeted nanoparticles in mice.Theranostics. 2018 Apr 9;8(10):2765-2781. doi: 10.7150/thno.22904. eCollection 2018. Theranostics. 2018. PMID: 29774074 Free PMC article.
-
Liposomes for Intra-Articular Analgesic Drug Delivery in Orthopedics: State-of-Art and Future Perspectives. Insights from a Systematic Mini-Review of the Literature.Medicina (Kaunas). 2020 Aug 20;56(9):423. doi: 10.3390/medicina56090423. Medicina (Kaunas). 2020. PMID: 32825518 Free PMC article.
-
The use of liposomal bupivacaine in fracture surgery: a review.J Orthop Surg Res. 2023 Apr 1;18(1):267. doi: 10.1186/s13018-023-03583-1. J Orthop Surg Res. 2023. PMID: 37005638 Free PMC article. Review.