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. 2015;54(2):141-6.
doi: 10.2169/internalmedicine.54.2858. Epub 2015 Jan 15.

The duration of diabetes is inversely associated with the physiological serum bilirubin levels in patients with type 2 diabetes

Jin Ook Chung  1 , Dong Hyeok Cho, Dong Jin Chung, Min Young Chung
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Free article

The duration of diabetes is inversely associated with the physiological serum bilirubin levels in patients with type 2 diabetes

Jin Ook Chung et al. Intern Med. 2015.
Free article

Abstract

Objective: The aim of this study was to assess the relationship between the duration of diabetes and the physiological serum bilirubin concentration in association with antioxidant properties in patients with type 2 diabetes.

Methods: A total of 1,746 patients with type 2 diabetes were investigated in this cross-sectional study. An analysis of covariance was performed after adjusting for other covariates. Simple correlation analyses and a multivariate regression model were used to assess the association between the duration of diabetes and the serum bilirubin concentration.

Results: The mean total bilirubin value differed significantly according to the tertile of diabetes duration (<5 years, 12.38 μmol/L, 95% confidence interval (CI) 12.02-12.76; 5-11.9 years, 12.33 μmol/L, 95% CI 11.97-12.69; ≥12 years, 11.73 μmol/L, 95% CI 11.35-12.11; p for trend =0.033), after adjustment for other covariates. In addition, an inverse correlation was found between the serum bilirubin concentration and diabetes duration (ρ=-0.211, p<0.001). According to a multivariate model, the association between the diabetes duration and serum bilirubin concentration remained significant, even after adjustment for confounding factors (β=-0.074, p=0.008).

Conclusion: The duration of diabetes is inversely associated with a serum bilirubin concentration within the physiologic range in patients with type 2 diabetes.

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