Review
doi: 10.1016/0165-6147(89)90065-5.
Is there a third heart beta-adrenoceptor?
- PMID: 2573966
- DOI: 10.1016/0165-6147(89)90065-5
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Review
Is there a third heart beta-adrenoceptor?
Trends Pharmacol Sci.
1989 Aug.
Abstract
A series of partial agonists with high affinity for myocardial beta 1- and beta 2-adrenoceptors cause stimulant effects in heart that are resistant to blockade of beta 1- and beta 2-adrenoceptors. The concentrations of partial agonist that cause stimulant effects greatly exceed those that cause blockade. Alberto Kaumann suggests that such non-conventional partial agonists, often analogues of pindolol, may act through a third heart beta-adrenoceptor, which resembles the beta 3-adrenoceptor of white adipocytes and smooth muscle of airways and ileum.
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