Oxidative stress responses in the human fungal pathogen, Candida albicans
- PMID: 25723552
- PMCID: PMC4384116
- DOI: 10.3390/biom5010142
Oxidative stress responses in the human fungal pathogen, Candida albicans
Abstract
Candida albicans is a major fungal pathogen of humans, causing approximately 400,000 life-threatening systemic infections world-wide each year in severely immunocompromised patients. An important fungicidal mechanism employed by innate immune cells involves the generation of toxic reactive oxygen species (ROS), such as superoxide and hydrogen peroxide. Consequently, there is much interest in the strategies employed by C. albicans to evade the oxidative killing by macrophages and neutrophils. Our understanding of how C. albicans senses and responds to ROS has significantly increased in recent years. Key findings include the observations that hydrogen peroxide triggers the filamentation of this polymorphic fungus and that a superoxide dismutase enzyme with a novel mode of action is expressed at the cell surface of C. albicans. Furthermore, recent studies have indicated that combinations of the chemical stresses generated by phagocytes can actively prevent C. albicans oxidative stress responses through a mechanism termed the stress pathway interference. In this review, we present an up-date of our current understanding of the role and regulation of oxidative stress responses in this important human fungal pathogen.
Figures



Similar articles
-
Mechanisms underlying the exquisite sensitivity of Candida albicans to combinatorial cationic and oxidative stress that enhances the potent fungicidal activity of phagocytes.mBio. 2014 Jul 15;5(4):e01334-14. doi: 10.1128/mBio.01334-14. mBio. 2014. PMID: 25028425 Free PMC article.
-
Candida albicans Sfp1 Is Involved in the Cell Wall and Endoplasmic Reticulum Stress Responses Induced by Human Antimicrobial Peptide LL-37.Int J Mol Sci. 2021 Sep 30;22(19):10633. doi: 10.3390/ijms221910633. Int J Mol Sci. 2021. PMID: 34638975 Free PMC article.
-
Integrative Model of Oxidative Stress Adaptation in the Fungal Pathogen Candida albicans.PLoS One. 2015 Sep 14;10(9):e0137750. doi: 10.1371/journal.pone.0137750. eCollection 2015. PLoS One. 2015. PMID: 26368573 Free PMC article.
-
Epigenetic Control of Oxidative Stresses by Histone Acetyltransferases in Candida albicans.J Microbiol Biotechnol. 2018 Feb 28;28(2):181-189. doi: 10.4014/jmb.1707.07029. J Microbiol Biotechnol. 2018. PMID: 29169224 Review.
-
Stress adaptation in a pathogenic fungus.J Exp Biol. 2014 Jan 1;217(Pt 1):144-55. doi: 10.1242/jeb.088930. J Exp Biol. 2014. PMID: 24353214 Free PMC article. Review.
Cited by
-
Effect of Nitric Oxide on the Antifungal Activity of Oxidative Stress and Azoles Against Candida albicans.Indian J Microbiol. 2016 Jun;56(2):214-218. doi: 10.1007/s12088-016-0580-x. Epub 2016 Apr 9. Indian J Microbiol. 2016. PMID: 27570314 Free PMC article.
-
Influence of ylHog1 MAPK kinase on Yarrowia lipolytica stress response and erythritol production.Sci Rep. 2018 Oct 3;8(1):14735. doi: 10.1038/s41598-018-33168-6. Sci Rep. 2018. PMID: 30283045 Free PMC article.
-
Plasma membrane architecture protects Candida albicans from killing by copper.PLoS Genet. 2019 Jan 11;15(1):e1007911. doi: 10.1371/journal.pgen.1007911. eCollection 2019 Jan. PLoS Genet. 2019. PMID: 30633741 Free PMC article.
-
The attenuation of antibiotic resistant non-albicans Candida species, cytotoxicity, anti-inflammatory effects and phytochemical profiles of five Vachellia species by FTIR and UHPLC-Q/Orbitrap/MS.Heliyon. 2021 Nov 19;7(11):e08425. doi: 10.1016/j.heliyon.2021.e08425. eCollection 2021 Nov. Heliyon. 2021. PMID: 34877423 Free PMC article.
-
The Transient Receptor Potential Channel Yvc1 Deletion Recovers the Growth Defect of Calcineurin Mutant Under Endoplasmic Reticulum Stress in Candida albicans.Front Microbiol. 2021 Nov 30;12:752670. doi: 10.3389/fmicb.2021.752670. eCollection 2021. Front Microbiol. 2021. PMID: 34917046 Free PMC article.
References
-
- Odds F.C. Candida and Candidosis. 2nd ed. Bailliere-Tindall; London, UK: 1988.
-
- Calderone R.A., Clancy C.J. Candida and Candidiasis. ASM Press; Washington, DC, USA: 2012.
-
- Anaissie E.J., McGinnis M.R., Pfaller M.A. Clinical Mycology. Churchill Livingstone; London, UK: 2009.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources