Prospects of boswellic acids as potential pharmaceutics
- PMID: 25714728
- DOI: 10.1055/s-0034-1396313
Prospects of boswellic acids as potential pharmaceutics
Abstract
Boswellic acids have long been considered the main bioactive components of frankincense, and many studies in vitro and in animals as well as several clinical studies have confirmed their various bioactivities. In particular, a large number of mechanistic studies have confirmed their anti-inflammatory and antitumor activities. However, not every boswellic acid exhibits a satisfactory pharmacological performance, which depends on the chemical structure and functional groups of the acid. To enhance the pharmacological values of boswellic acids, derivatization has been specifically applied with the aim of discovering more active derivatives of BAs. In addition, the preliminary pharmacokinetic studies of these compounds using various standard methods show their poor bioavailability in humans and rodents, which has led to questions of their pharmacological relevance and potentially limits their use in clinical practice and pharmaceutical development. To improve these effects, some approaches have shown some improvements in effectiveness, and the new formula compatibility approach is considered a very reasonable method for improving the bioavailability of boswellic acids.
Georg Thieme Verlag KG Stuttgart · New York.
Similar articles
-
Modulation of Pgp function by boswellic acids.Planta Med. 2006 May;72(6):507-13. doi: 10.1055/s-2006-931536. Planta Med. 2006. PMID: 16773534
-
In vitro metabolism, permeation, and brain availability of six major boswellic acids from Boswellia serrata gum resins.Fitoterapia. 2013 Jan;84:99-106. doi: 10.1016/j.fitote.2012.10.009. Epub 2012 Oct 24. Fitoterapia. 2013. PMID: 23103296
-
Characterization of 3alpha-acetyl-11-keto-alpha-boswellic acid, a pentacyclic triterpenoid inducing apoptosis in vitro and in vivo.Planta Med. 2006 Nov;72(14):1285-9. doi: 10.1055/s-2006-951680. Epub 2006 Oct 4. Planta Med. 2006. PMID: 17022003
-
Pharmacological evidences for cytotoxic and antitumor properties of Boswellic acids from Boswellia serrata.J Ethnopharmacol. 2016 Sep 15;191:315-323. doi: 10.1016/j.jep.2016.06.053. Epub 2016 Jun 21. J Ethnopharmacol. 2016. PMID: 27346540 Review.
-
Boswellic acids in chronic inflammatory diseases.Planta Med. 2006 Oct;72(12):1100-16. doi: 10.1055/s-2006-947227. Planta Med. 2006. PMID: 17024588 Review.
Cited by
-
The Anti-Inflammatory and Immunomodulatory Activities of Natural Products to Control Autoimmune Inflammation.Int J Mol Sci. 2022 Dec 21;24(1):95. doi: 10.3390/ijms24010095. Int J Mol Sci. 2022. PMID: 36613560 Free PMC article. Review.
-
Googling the Guggul (Commiphora and Boswellia) for Prevention of Chronic Diseases.Front Pharmacol. 2018 Aug 6;9:686. doi: 10.3389/fphar.2018.00686. eCollection 2018. Front Pharmacol. 2018. PMID: 30127736 Free PMC article. Review.
-
Targeting Inflammatory Pathways in Alzheimer's Disease: A Focus on Natural Products and Phytomedicines.CNS Drugs. 2019 May;33(5):457-480. doi: 10.1007/s40263-019-00619-1. CNS Drugs. 2019. PMID: 30900203 Review.
-
Exploring the Promising Role of Guggulipid in Rheumatoid Arthritis Management: An In-depth Analysis.Curr Rheumatol Rev. 2024;20(5):469-487. doi: 10.2174/0115733971280984240101115203. Curr Rheumatol Rev. 2024. PMID: 38284718 Review.
-
Investigation of Molecular Properties that Influence the Permeability and Oral Bioavailability of Major β-Boswellic Acids.Eur J Drug Metab Pharmacokinet. 2020 Apr;45(2):243-255. doi: 10.1007/s13318-019-00599-z. Eur J Drug Metab Pharmacokinet. 2020. PMID: 31786725
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
