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. 1989 Aug 5;2(8658):294-7.
doi: 10.1016/s0140-6736(89)90485-6.

Hepatitis C virus antibodies among risk groups in Spain

J I Esteban  1 , R Esteban, L Viladomiu, J C López-Talavera, A González, J M Hernández, M Roget, V Vargas, J Genescà, M Buti, et al.
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Hepatitis C virus antibodies among risk groups in Spain

J I Esteban et al. Lancet. .

Abstract

The frequency of hepatitis C virus (HCV) infection in Spain was assessed by means of a recombinant-based immunoassay for serum anti-HCV antibodies. 836 serum samples were tested from 676 patients selected according to their risk of blood-borne viral infections and presence of liver disease. Among patients at high risk of infection (with or without liver disease) anti-HCV antibodies were found in 85% of prospectively followed patients with post-transfusion non-A, non-B hepatitis, 62% of patients with chronic hepatitis or cirrhosis and a history of blood transfusion, 70% of haemophiliacs receiving replacement therapy, 70% of intravenous drug abusers, and 20% of haemodialysis patients. Only 8% of homosexual men infected with human immunodeficiency virus and 6% of female contacts of drug abusers were positive. Among patients with liver disease and no history of parenteral exposure to blood, anti-HCV antibodies were detected in 38% with cryptogenic, alcoholic, or primary biliary cirrhosis and in 44% with chronic active hepatitis. Among healthy subjects without risk factors for hepatitis the overall prevalence of anti-HCV was 1.2%.

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