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Review
. 2015 Apr;294(2):63-9.
doi: 10.1016/j.cellimm.2015.01.018. Epub 2015 Feb 7.

Estrogen receptors regulate innate immune cells and signaling pathways

Susan Kovats  1
Affiliations
Review

Estrogen receptors regulate innate immune cells and signaling pathways

Susan Kovats. Cell Immunol. 2015 Apr.

Abstract

Humans show strong sex differences in immunity to infection and autoimmunity, suggesting sex hormones modulate immune responses. Indeed, receptors for estrogens (ERs) regulate cells and pathways in the innate and adaptive immune system, as well as immune cell development. ERs are ligand-dependent transcription factors that mediate long-range chromatin interactions and form complexes at gene regulatory elements, thus promoting epigenetic changes and transcription. ERs also participate in membrane-initiated steroid signaling to generate rapid responses. Estradiol and ER activity show profound dose- and context-dependent effects on innate immune signaling pathways and myeloid cell development. While estradiol most often promotes the production of type I interferon, innate pathways leading to pro-inflammatory cytokine production may be enhanced or dampened by ER activity. Regulation of innate immune cells and signaling by ERs may contribute to the reported sex differences in innate immune pathways. Here we review the recent literature and highlight several molecular mechanisms by which ERs regulate the development or functional responses of innate immune cells.

Keywords: Antigen-presenting cells; Cellular differentiation; Dendritic cells; Estrogen receptor; Hematopoiesis; Inflammation; Innate immune signaling; Macrophages; Sex differences; Sex hormone.

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References

    1. Heldring N, Pike A, Andersson S, Matthews J, Cheng G, Hartman J, Tujague M, Strom A, Treuter E, Warner M, Gustafsson JA. Estrogen receptors: how do they signal and what are their targets. Physiol Rev. 2007;87:905–931. - PubMed
    1. Laffont S, Rouquie N, Azar P, Seillet C, Plumas J, Aspord C, Guery JC. X-Chromosome Complement and Estrogen Receptor Signaling Independently Contribute to the Enhanced TLR7-Mediated IFN-alpha Production of Plasmacytoid Dendritic Cells from Women. J Immunol. 2014;193:5444–5452. - PubMed
    1. Phiel KL, Henderson RA, Adelman SJ, Elloso MM. Differential estrogen receptor gene expression in human peripheral blood mononuclear cell populations. Immunol Lett. 2005;97:107–113. - PubMed
    1. Mor G, Sapi E, Abrahams VM, Rutherford T, Song J, Hao XY, Muzaffar S, Kohen F. Interaction of the estrogen receptors with the Fas ligand promoter in human monocytes. J Immunol. 2003;170:114–122. - PubMed
    1. Escribese MM, Kraus T, Rhee E, Fernandez-Sesma A, Lopez CB, Moran TM. Estrogen inhibits dendritic cell maturation to RNA viruses. Blood. 2008;112:4574–4584. - PMC - PubMed

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