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. 2015 Aug 26;33(36):4653-8.
doi: 10.1016/j.vaccine.2014.08.091. Epub 2015 Feb 11.

Immunogenicity and persistence from different 3-dose schedules of live and inactivated polio vaccines in Chinese infants

Li Lu  1 , Xiaomei Li  2 , Herun Zhang  2 , Donglei Liu  2 , Zhujiazi Zhang  2 , Haihong Wang  3 , Fang Liu  4 , Zhaoqi Ning  5 , Juan Li  2 , Xinghuo Pang  2
Affiliations

Immunogenicity and persistence from different 3-dose schedules of live and inactivated polio vaccines in Chinese infants

Li Lu et al. Vaccine. .

Abstract

Background: OPV is the only poliovirus vaccine used in the China EPI system, although IPV is available in the private market. We compared immunigencity and persistence among different schedules of IPV and OPV.

Methods: 536 Chinese infants were enrolled into 4 groups receiving different schedules administered at 2, 3, and 4 months of age: IPV-OPV-OPV, IPV-IPV-OPV, IPV-IPV-IPV, and OPV-OPV-OPV. The I-I-I group received an 18-month IPV booster dose. Blood samples were collected before the first dose, after the third dose, and at 18 months for all groups, and also after the booster dose for the I-I-I group. Polio neutralizing antibody titers were assessed, and seroprotection rates were calculated after primary immunization and at 18 months of age.

Results: Before the first dose, GMTs of the 4 groups ranged from 2.96 to 6.89, and seroprotection rates ranged from 17.6% to 54.3%. After 3 doses, the GMT of the I-O-O and I-I-O groups ranged from 901.09 to 1,110.12, and the GMT of the I-I-I group range was 212.02 to 537.52, significantly lower than for the 2 sequential schedules (P<0.001). Seroprotection rates were 98.1% to 100%, with no significant differences among groups. At 18 months of age, the GMTs declined to a range of 527.00 to 683.44 in the I-O-O and I-I-O groups, and declined to 150.04 to 239.89 in the I-I-I group, significantly lower than for the other 3 groups (P<0.001).

Conclusions: The sequential schedules achieved high GMTs and seroprotection. The IPV-only schedule achieved high seroprotection but with lower GMTs. Sequential schedules are suitable for China. With the 2 sequential schedules, GMTs remained high at 18 months of age and were not inferior to the OPV-only schedule. Thus, with a sequential schedule, the booster dose could be given at 4 years of age, the same age as the current OPV booster dose.

Keywords: IPV; Immunogencity; OPV; Persistence; Polio vaccine; Sequential schedule.

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