Cancer stem cell: fundamental experimental pathological concepts and updates

doi:10.1016/j.yexmp.2015.02.002

Review

. 2015 Apr;98(2):184-91.

doi: 10.1016/j.yexmp.2015.02.002. Epub 2015 Feb 7.

Cancer stem cell: fundamental experimental pathological concepts and updates

Farhadul Islam¹, Bin Qiao², Robert A Smith³, Vinod Gopalan¹, Alfred K-Y Lam⁴

Affiliations

¹ Cancer Molecular Pathology, School of Medicine and Griffith Health Institute, Griffith University, Gold Coast, Queensland, Australia.
² Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
³ Cancer Molecular Pathology, School of Medicine and Griffith Health Institute, Griffith University, Gold Coast, Queensland, Australia; Genomics Research Centre, Institute of Health and Biomedical Innovation, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia.
⁴ Cancer Molecular Pathology, School of Medicine and Griffith Health Institute, Griffith University, Gold Coast, Queensland, Australia; Department of Pathology, Gold Coast University Hospital, Gold Coast, Queensland, Australia. Electronic address: a.lam@griffith.edu.au.

PMID: 25659759
DOI: 10.1016/j.yexmp.2015.02.002

Review

Cancer stem cell: fundamental experimental pathological concepts and updates

Farhadul Islam et al. Exp Mol Pathol. 2015 Apr.

. 2015 Apr;98(2):184-91.

doi: 10.1016/j.yexmp.2015.02.002. Epub 2015 Feb 7.

Authors

Farhadul Islam¹, Bin Qiao², Robert A Smith³, Vinod Gopalan¹, Alfred K-Y Lam⁴

Affiliations

¹ Cancer Molecular Pathology, School of Medicine and Griffith Health Institute, Griffith University, Gold Coast, Queensland, Australia.
² Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
³ Cancer Molecular Pathology, School of Medicine and Griffith Health Institute, Griffith University, Gold Coast, Queensland, Australia; Genomics Research Centre, Institute of Health and Biomedical Innovation, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia.
⁴ Cancer Molecular Pathology, School of Medicine and Griffith Health Institute, Griffith University, Gold Coast, Queensland, Australia; Department of Pathology, Gold Coast University Hospital, Gold Coast, Queensland, Australia. Electronic address: a.lam@griffith.edu.au.

PMID: 25659759
DOI: 10.1016/j.yexmp.2015.02.002

Abstract

Cancer stem cells (CSCs) are a subset of cancer cells which play a key role in predicting the biological aggressiveness of cancer due to its ability of self-renewal and multi-lineage differentiation (stemness). The CSC model is a dynamic one with a functional subpopulation of cancer cells rather than a stable cell population responsible for tumour regeneration. Hypotheses regarding the origins of CSCs include (1) malignant transformation of normal stem cells; (2) mature cancer cell de-differentiation with epithelial-mesenchymal transition and (3) induced pluripotent cancer cells. Surprisingly, the cancer stem cell hypothesis originated in the late nineteenth century and the existence of haematopoietic stem cells was demonstrated a century later, demonstrating that the concept was possible. In the last decade, CSCs have been identified and isolated in different cancers. The hallmark traits of CSCs include their heterogeneity, interaction with microenvironments and plasticity. Understanding these basic concepts of CSCs is important for translational applications using CSCs in the management of patients with cancer.

Keywords: Cancer stem cell; Heterogeneity; Microenvironment; Origin; Plasticity.

PubMed Disclaimer

Cited by

Metabolic Reprograming Via Silencing of Mitochondrial VDAC1 Expression Encourages Differentiation of Cancer Cells.
Arif T, Amsalem Z, Shoshan-Barmatz V. Arif T, et al. Mol Ther Nucleic Acids. 2019 Sep 6;17:24-37. doi: 10.1016/j.omtn.2019.05.003. Epub 2019 May 18. Mol Ther Nucleic Acids. 2019. PMID: 31195298 Free PMC article.
Therapeutic strategies targeting cancer stem cells.
Yoshida GJ, Saya H. Yoshida GJ, et al. Cancer Sci. 2016 Jan;107(1):5-11. doi: 10.1111/cas.12817. Epub 2015 Oct 21. Cancer Sci. 2016. PMID: 26362755 Free PMC article. Review.
Regulation of tumorigenesis in oral epithelial cells by defined reprogramming factors Oct4 and Sox2.
Cai J, He B, Li X, Sun M, Lam AK, Qiao B, Qiu W. Cai J, et al. Oncol Rep. 2016 Aug;36(2):651-8. doi: 10.3892/or.2016.4851. Epub 2016 Jun 3. Oncol Rep. 2016. PMID: 27279579 Free PMC article.
The Roles of Autophagy in Cancer.
Yun CW, Lee SH. Yun CW, et al. Int J Mol Sci. 2018 Nov 5;19(11):3466. doi: 10.3390/ijms19113466. Int J Mol Sci. 2018. PMID: 30400561 Free PMC article. Review.
Thyrospheres from B-CPAP Cell Line with BRAF and TERT Promoter Mutations have Different Functional and Molecular Features than Parental Cells.
Caria P, Pillai R, Dettori T, Frau DV, Zavattari P, Riva G, Romano G, Pani F, Bentivegna A, Giovannoni R, Pagni F, Sogos V, Vanni R. Caria P, et al. J Cancer. 2017 Jun 3;8(9):1629-1639. doi: 10.7150/jca.18855. eCollection 2017. J Cancer. 2017. PMID: 28775782 Free PMC article.

See all "Cited by" articles

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Elsevier Science

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Cancer stem cell: fundamental experimental pathological concepts and updates

Affiliations

Cancer stem cell: fundamental experimental pathological concepts and updates

Authors

Affiliations

Abstract

Similar articles

Cited by

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources