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Review
. 2015 Mar;9(1):10-9.
doi: 10.1007/s11684-015-0388-9. Epub 2015 Feb 4.

Th17 cells in autoimmune diseases

Lei Han  1 , Jing Yang, Xiuwen Wang, Dan Li, Ling Lv, Bin Li
Affiliations
Review

Th17 cells in autoimmune diseases

Lei Han et al. Front Med. 2015 Mar.

Abstract

Th17 cells are a new subset of CD4(+) T cells involved in the clearance of extracellular pathogens and fungi. Accumulating evidence suggests that Th17 cells and their signature cytokines have a pivotal role in the pathogenesis of multiple autoimmune-mediated inflammatory diseases. Here, we summarize recent research progress on Th17 function in the development and pathogenesis of autoimmune diseases. We also propose to identify new small molecule compounds to manipulate Th17 function for potential therapeutic application to treat human autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, Sjögren's syndrome, inflammatory bowel disease, and multiple sclerosis.

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