Effect of surface chemistry on the integrin induced pathway in regulating vascular endothelial cells migration

doi:10.1016/j.colsurfb.2014.12.019

Review

. 2015 Feb 1:126:188-97.

doi: 10.1016/j.colsurfb.2014.12.019. Epub 2014 Dec 30.

Effect of surface chemistry on the integrin induced pathway in regulating vascular endothelial cells migration

Yang Shen¹, Min Gao¹, Yunlong Ma¹, Hongchi Yu¹, Fu-zhai Cui², Hans Gregersen³, Qingsong Yu⁴, Guixue Wang³, Xiaoheng Liu⁵

Affiliations

¹ Institute of Biomedical Engineering, School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, PR China.
² State Key Laboratory of New Ceramics and Fine Processing, Department of Material Science and Engineering, Tsinghua University, Beijing 100084, PR China.
³ Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, Bioengineering College of Chongqing University, Chongqing 400030, PR China.
⁴ Center for Surface Science and Plasma Technology, Department of Mechanical and Aerospace Engineering, University of Missouri, Columbia, MO 65211, USA.
⁵ Institute of Biomedical Engineering, School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, PR China. Electronic address: liuxiaohg@scu.edu.cn.

PMID: 25575348
DOI: 10.1016/j.colsurfb.2014.12.019

Review

Effect of surface chemistry on the integrin induced pathway in regulating vascular endothelial cells migration

Yang Shen et al. Colloids Surf B Biointerfaces. 2015.

. 2015 Feb 1:126:188-97.

doi: 10.1016/j.colsurfb.2014.12.019. Epub 2014 Dec 30.

Authors

Yang Shen¹, Min Gao¹, Yunlong Ma¹, Hongchi Yu¹, Fu-zhai Cui², Hans Gregersen³, Qingsong Yu⁴, Guixue Wang³, Xiaoheng Liu⁵

Affiliations

¹ Institute of Biomedical Engineering, School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, PR China.
² State Key Laboratory of New Ceramics and Fine Processing, Department of Material Science and Engineering, Tsinghua University, Beijing 100084, PR China.
³ Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, Bioengineering College of Chongqing University, Chongqing 400030, PR China.
⁴ Center for Surface Science and Plasma Technology, Department of Mechanical and Aerospace Engineering, University of Missouri, Columbia, MO 65211, USA.
⁵ Institute of Biomedical Engineering, School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, PR China. Electronic address: liuxiaohg@scu.edu.cn.

PMID: 25575348
DOI: 10.1016/j.colsurfb.2014.12.019

Abstract

The migration of vascular endothelial cells (ECs) is essential for reendothelialization after implantation of cardiovascular biomaterials. Reendothelialization is largely determined by surface properties of implants. In this study, surfaces modified with various chemical functional groups (CH3, NH2, COOH, OH) prepared by self-assembled monolayers (SAMs) were used as model system. Expressions and distributions of critical proteins in the integrin-induced signaling pathway were examined to explore the mechanisms of surface chemistry regulating EC migration. The results showed that SAMs modulated cell migration were in the order CH3>NH2>OH>COOH, determined by differences in the expressions of focal adhesion components and Rho GTPases. Multiple integrin subunits showed difference in a surface chemistry-dependent manner, which induced a stepwise activation of signaling cascades associated with EC migration. This work provides a broad overview of surface chemistry regulated endothelial cell migration and establishes association among the surface chemistry, cell migration behavior and associated integrin signaling events. Understanding the relationship between these factors will help us to understand the surface/interface behavior between biomaterials and cells, reveal molecular mechanism of cells sensing surface characterization, and guide surface modification of cardiovascular implanted materials.

Keywords: Cell adhesion/migration; FAK; Focal adhesion; Rho GTPases; Surface chemistry.

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Effect of surface chemistry on the integrin induced pathway in regulating vascular endothelial cells migration

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Effect of surface chemistry on the integrin induced pathway in regulating vascular endothelial cells migration

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