Silver nanoparticles: synthesis, properties, and therapeutic applications

doi:10.1016/j.drudis.2014.11.014

Review

. 2015 May;20(5):595-601.

doi: 10.1016/j.drudis.2014.11.014. Epub 2014 Dec 24.

Silver nanoparticles: synthesis, properties, and therapeutic applications

Liuya Wei¹, Jingran Lu², Huizhong Xu³, Atish Patel⁴, Zhe-Sheng Chen⁵, Guofang Chen⁶

Affiliations

¹ School of Pharmacy, Weifang Medical University, Weifang 261053, People's Republic of China; Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John's University, Queens, NY 11439, USA.
² Department of Chemistry, St John's College of Liberal Arts and Science, St John's University, Queens, NY 11439, USA.
³ Department of Physics, St John's College of Liberal Arts and Science, St John's University, Queens, NY 11439, USA.
⁴ Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John's University, Queens, NY 11439, USA.
⁵ Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John's University, Queens, NY 11439, USA. Electronic address: chenz@stjohns.edu.
⁶ Department of Chemistry, St John's College of Liberal Arts and Science, St John's University, Queens, NY 11439, USA. Electronic address: gfchen08@yahoo.com.

PMID: 25543008
PMCID: PMC4433816
DOI: 10.1016/j.drudis.2014.11.014

Review

Silver nanoparticles: synthesis, properties, and therapeutic applications

Liuya Wei et al. Drug Discov Today. 2015 May.

. 2015 May;20(5):595-601.

doi: 10.1016/j.drudis.2014.11.014. Epub 2014 Dec 24.

Authors

Liuya Wei¹, Jingran Lu², Huizhong Xu³, Atish Patel⁴, Zhe-Sheng Chen⁵, Guofang Chen⁶

Affiliations

¹ School of Pharmacy, Weifang Medical University, Weifang 261053, People's Republic of China; Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John's University, Queens, NY 11439, USA.
² Department of Chemistry, St John's College of Liberal Arts and Science, St John's University, Queens, NY 11439, USA.
³ Department of Physics, St John's College of Liberal Arts and Science, St John's University, Queens, NY 11439, USA.
⁴ Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John's University, Queens, NY 11439, USA.
⁵ Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John's University, Queens, NY 11439, USA. Electronic address: chenz@stjohns.edu.
⁶ Department of Chemistry, St John's College of Liberal Arts and Science, St John's University, Queens, NY 11439, USA. Electronic address: gfchen08@yahoo.com.

PMID: 25543008
PMCID: PMC4433816
DOI: 10.1016/j.drudis.2014.11.014

Abstract

Silver nanoparticles (AgNPs) have been widely used in biomedical fields because of their intrinsic therapeutic properties. Here, we introduce methods of synthesizing AgNPs and discuss their physicochemical, localized surface plasmon resonance (LSPR) and toxicity properties. We also review the impact of AgNPs on human health and the environment along with the underlying mechanisms. More importantly, we highlight the newly emerging applications of AgNPs as antiviral agents, photosensitizers and/or radiosensitizers, and anticancer therapeutic agents in the treatment of leukemia, breast cancer, hepatocellular carcinoma, lung cancer, and skin and/or oral carcinoma.

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Figures

**Figure 1**
Schematic representation of possible mechanisms for silver nanoparticle (AgNP)-induced cytotoxicity. The red circles denote AgNPs. Abbreviation: ROS, reactive oxygen species.

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References

1. Habouti S, et al. Synthesis of silver nano-fir-twigs and application to single molecules detection. J Mater Chem. 2010;20:5215–5219.
1. Hu XH, Chan CT. Photonic crystals with silver nanowires as a near-infrared superlens. Appl Phys Lett. 2004;85:1520–1522.
1. Alshehri AH, et al. Enhanced electrical conductivity of silver nanoparticles for high frequency electronic applications. ACS Appl Mater Interfaces. 2012;4:7007–7010. - PubMed
1. Chen G, et al. A novel green synthesis approach for polymer nanocomposites decorated with silver nanoparticles and their antibacterial activity. Analyst. 2014;139:5793–5799. - PubMed
1. Braun GB, et al. Etchable plasmonic nanoparticle probes to image and quantify cellular internalization. Nat Mater. 2014;13:904–911. - PMC - PubMed

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R15 CA143701/CA/NCI NIH HHS/United States

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[1] Habouti S, et al. Synthesis of silver nano-fir-twigs and application to single molecules detection. J Mater Chem. 2010;20:5215–5219.

[2] Habouti S, et al. Synthesis of silver nano-fir-twigs and application to single molecules detection. J Mater Chem. 2010;20:5215–5219.

[3] Hu XH, Chan CT. Photonic crystals with silver nanowires as a near-infrared superlens. Appl Phys Lett. 2004;85:1520–1522.

[4] Hu XH, Chan CT. Photonic crystals with silver nanowires as a near-infrared superlens. Appl Phys Lett. 2004;85:1520–1522.

[5] Alshehri AH, et al. Enhanced electrical conductivity of silver nanoparticles for high frequency electronic applications. ACS Appl Mater Interfaces. 2012;4:7007–7010. - PubMed

[6] Alshehri AH, et al. Enhanced electrical conductivity of silver nanoparticles for high frequency electronic applications. ACS Appl Mater Interfaces. 2012;4:7007–7010. - PubMed

[7] Chen G, et al. A novel green synthesis approach for polymer nanocomposites decorated with silver nanoparticles and their antibacterial activity. Analyst. 2014;139:5793–5799. - PubMed

[8] Chen G, et al. A novel green synthesis approach for polymer nanocomposites decorated with silver nanoparticles and their antibacterial activity. Analyst. 2014;139:5793–5799. - PubMed

[9] Braun GB, et al. Etchable plasmonic nanoparticle probes to image and quantify cellular internalization. Nat Mater. 2014;13:904–911. - PMC - PubMed

[10] Braun GB, et al. Etchable plasmonic nanoparticle probes to image and quantify cellular internalization. Nat Mater. 2014;13:904–911. - PMC - PubMed

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Silver nanoparticles: synthesis, properties, and therapeutic applications

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Silver nanoparticles: synthesis, properties, and therapeutic applications

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