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. 1989 Nov;63(11):4949-51.
doi: 10.1128/JVI.63.11.4949-4951.1989.

Nucleotide sequence of a neurovirulent variant of the type 2 oral poliovirus vaccine

S R Pollard  1 , G Dunn, N Cammack, P D Minor, J W Almond
Affiliations

Nucleotide sequence of a neurovirulent variant of the type 2 oral poliovirus vaccine

S R Pollard et al. J Virol. 1989 Nov.

Abstract

Infectious cDNAs of the Sabin type 2 poliovirus vaccine virus and a vaccine-derived neurovirulent type 2 strain (P2/117) have been cloned in Escherichia coli. Nucleotide sequence analysis revealed that P2/117 differs from the vaccine strain by just 23 point mutations. Three occur in the 5' noncoding region. The remainder result in a total of 5 coding changes located in VP1, VP4, 2B, and 3D. The likely role of these mutations in the evolution to neurovirulence is discussed.

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