The risk-associated long noncoding RNA NBAT-1 controls neuroblastoma progression by regulating cell proliferation and neuronal differentiation
- PMID: 25517750
- DOI: 10.1016/j.ccell.2014.09.014
The risk-associated long noncoding RNA NBAT-1 controls neuroblastoma progression by regulating cell proliferation and neuronal differentiation
Abstract
Neuroblastoma is an embryonal tumor of the sympathetic nervous system and the most common extracranial tumor of childhood. By sequencing transcriptomes of low- and high-risk neuroblastomas, we detected differentially expressed annotated and nonannotated long noncoding RNAs (lncRNAs). We identified a lncRNA neuroblastoma associated transcript-1 (NBAT-1) as a biomarker significantly predicting clinical outcome of neuroblastoma. CpG methylation and a high-risk neuroblastoma associated SNP on chromosome 6p22 functionally contribute to NBAT-1 differential expression. Loss of NBAT-1 increases cellular proliferation and invasion. It controls these processes via epigenetic silencing of target genes. NBAT-1 loss affects neuronal differentiation through activation of the neuronal-specific transcription factor NRSF/REST. Thus, loss of NBAT-1 contributes to aggressive neuroblastoma by increasing proliferation and impairing differentiation of neuronal precursors.
Copyright © 2014 Elsevier Inc. All rights reserved.
Similar articles
-
CASC15-S Is a Tumor Suppressor lncRNA at the 6p22 Neuroblastoma Susceptibility Locus.Cancer Res. 2015 Aug 1;75(15):3155-66. doi: 10.1158/0008-5472.CAN-14-3613. Epub 2015 Jun 22. Cancer Res. 2015. PMID: 26100672 Free PMC article.
-
N-myc and noncoding RNAs in neuroblastoma.Mol Cancer Res. 2012 Oct;10(10):1243-53. doi: 10.1158/1541-7786.MCR-12-0244. Epub 2012 Aug 30. Mol Cancer Res. 2012. PMID: 22936790 Review.
-
LncRNA NBAT-1 is down-regulated in lung cancer and influences cell proliferation, apoptosis and cell cycle.Eur Rev Med Pharmacol Sci. 2018 Apr;22(7):1958-1962. doi: 10.26355/eurrev_201804_14721. Eur Rev Med Pharmacol Sci. 2018. PMID: 29687849
-
Roles of long noncoding RNAs in brain development, functional diversification and neurodegenerative diseases.Brain Res Bull. 2013 Aug;97:69-80. doi: 10.1016/j.brainresbull.2013.06.001. Epub 2013 Jun 10. Brain Res Bull. 2013. PMID: 23756188 Review.
-
Long noncoding RNAs associated with liver regeneration 1 accelerates hepatocyte proliferation during liver regeneration by activating Wnt/β-catenin signaling.Hepatology. 2013 Aug;58(2):739-51. doi: 10.1002/hep.26361. Epub 2013 Jul 1. Hepatology. 2013. PMID: 23483581
Cited by
-
Identification of RNA-Binding Proteins as Targetable Putative Oncogenes in Neuroblastoma.Int J Mol Sci. 2020 Jul 19;21(14):5098. doi: 10.3390/ijms21145098. Int J Mol Sci. 2020. PMID: 32707690 Free PMC article.
-
Integrative analysis reveals clinical phenotypes and oncogenic potentials of long non-coding RNAs across 15 cancer types.Oncotarget. 2016 Jun 7;7(23):35044-55. doi: 10.18632/oncotarget.9037. Oncotarget. 2016. PMID: 27147563 Free PMC article.
-
Long Noncoding RNA in Digestive Tract Cancers: Function, Mechanism, and Potential Biomarker.Oncologist. 2015 Aug;20(8):898-906. doi: 10.1634/theoncologist.2014-0475. Epub 2015 Jul 8. Oncologist. 2015. PMID: 26156325 Free PMC article. Review.
-
N6-methyladenosine-mediated overexpression of long noncoding RNA ADAMTS9-AS2 triggers neuroblastoma differentiation via regulating LIN28B/let-7/MYCN signaling.JCI Insight. 2023 Nov 22;8(22):e165703. doi: 10.1172/jci.insight.165703. JCI Insight. 2023. PMID: 37991019 Free PMC article.
-
Long Non-Coding RNA in the Pathogenesis of Cancers.Cells. 2019 Sep 1;8(9):1015. doi: 10.3390/cells8091015. Cells. 2019. PMID: 31480503 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical