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. 1989 Jun 22;339(6226):597-603.
doi: 10.1038/339597a0.

Structural parts involved in activation and inactivation of the sodium channel

W Stühmer  1 , F Conti, H Suzuki, X D Wang, M Noda, N Yahagi, H Kubo, S Numa
Affiliations

Structural parts involved in activation and inactivation of the sodium channel

W Stühmer et al. Nature. .

Abstract

Structure-function relationships of the sodium channel expressed in Xenopus oocytes have been investigated by the combined use of site-directed mutagenesis and patch-clamp recording. This study provides evidence that the positive charges in segment S4 are involved in the voltage-sensing mechanism for activation of the channel and that the region between repeats III and IV is important for its inactivation.

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