Gut endoderm takes flight from the wings of mesoderm

doi:10.1038/ncb3077

Comment

. 2014 Dec;16(12):1128-9.

doi: 10.1038/ncb3077.

Gut endoderm takes flight from the wings of mesoderm

Angela C H McDonald¹, Janet Rossant²

Affiliations

¹ 1] Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, Peter Gilgan Centre for Research and Learning, 686 Bay Street, Toronto, Ontario M5G OA4, Canada [2] Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College Street, Toronto, Ontario M5S 3G9, Canada.
² 1] Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, Peter Gilgan Centre for Research and Learning, 686 Bay Street, Toronto, Ontario M5G OA4, Canada [2] Department of Molecular Genetics, University of Toronto, 1 King's College Circle, Toronto Ontario M5S 1A8, Canada.

PMID: 25434463
DOI: 10.1038/ncb3077

Comment

Gut endoderm takes flight from the wings of mesoderm

Angela C H McDonald et al. Nat Cell Biol. 2014 Dec.

. 2014 Dec;16(12):1128-9.

doi: 10.1038/ncb3077.

Authors

Angela C H McDonald¹, Janet Rossant²

Affiliations

¹ 1] Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, Peter Gilgan Centre for Research and Learning, 686 Bay Street, Toronto, Ontario M5G OA4, Canada [2] Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College Street, Toronto, Ontario M5S 3G9, Canada.
² 1] Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, Peter Gilgan Centre for Research and Learning, 686 Bay Street, Toronto, Ontario M5G OA4, Canada [2] Department of Molecular Genetics, University of Toronto, 1 King's College Circle, Toronto Ontario M5S 1A8, Canada.

PMID: 25434463
DOI: 10.1038/ncb3077

Abstract

The endoderm layer destined to be primitive gut is a mosaic of earlier visceral endoderm and definitive endoderm that arises later, during gastrulation. Live imaging now reveals that in mouse embryos, definitive endoderm cells egress from underlying mesoderm and intercalate into the overlying cell layer. This process requires SOX17-mediated control of basement membrane organization.

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SOX17 links gut endoderm morphogenesis and germ layer segregation.
Viotti M, Nowotschin S, Hadjantonakis AK. Viotti M, et al. Nat Cell Biol. 2014 Dec;16(12):1146-56. doi: 10.1038/ncb3070. Epub 2014 Nov 24. Nat Cell Biol. 2014. PMID: 25419850 Free PMC article.

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Gut endoderm takes flight from the wings of mesoderm

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Gut endoderm takes flight from the wings of mesoderm

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