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Review
. 2015 Jan;26(1):21-9.
doi: 10.1016/j.nec.2014.09.001.

Histology and molecular aspects of central neurocytoma

Phillip A Bonney  1 , Lillian B Boettcher  1 , Richard S Krysiak 3rd  1 , Kar-Ming Fung  2 , Michael E Sughrue  3
Affiliations
Review

Histology and molecular aspects of central neurocytoma

Phillip A Bonney et al. Neurosurg Clin N Am. 2015 Jan.

Abstract

Central neurocytoma (CN) is a well-differentiated tumor of neural cells occurring within the ventricles. It is composed of monomorphic cells with round, regular nuclei within clear cytoplasm and must be distinguished from other clear cell tumors. Immunohistochemical markers of CN that aid in diagnosis include synaptophysin and neuronal nuclear antigen. The molecular biology of these tumors is becoming increasingly elucidated, particularly with the use of microarray analyses. Several oncogenic pathways have been suggested by these studies. Although progress continues to be made, knowledge of CN has yet to dictate targeted therapies in treating patients with these tumors.

Keywords: Brain tumor; Central neurocytoma; Histology; Molecular pathways; Review.

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