Circulating cells contribute to cardiomyocyte regeneration after injury

doi:10.1161/CIRCRESAHA.116.304564

. 2015 Feb 13;116(4):633-41.

doi: 10.1161/CIRCRESAHA.116.304564. Epub 2014 Nov 14.

Circulating cells contribute to cardiomyocyte regeneration after injury

Jasmine M F Wu¹, Ying-Chang Hsueh¹, Hui-Ju Ch'ang¹, Chwan-Yau Luo¹, Li-Wha Wu¹, Hiromitsu Nakauchi¹, Patrick C H Hsieh²

Affiliations

¹ From the Institute of Basic Medical Sciences (J.M.F.W., Y.-C.H.) and Institute of Molecular Medicine (L.-W.W.), College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Surgery (C.-Y.L.) and Department of Radiation Oncology (H.-J.C.), National Cheng Kung University Hospital, Tainan, Taiwan; National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan (H.-J.C.); Division of Stem Cell Therapy, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan (H.N.); and Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan (P.C. H.H.).
² From the Institute of Basic Medical Sciences (J.M.F.W., Y.-C.H.) and Institute of Molecular Medicine (L.-W.W.), College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Surgery (C.-Y.L.) and Department of Radiation Oncology (H.-J.C.), National Cheng Kung University Hospital, Tainan, Taiwan; National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan (H.-J.C.); Division of Stem Cell Therapy, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan (H.N.); and Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan (P.C. H.H.). phsieh@ibms.sinica.edu.tw.

PMID: 25398235
DOI: 10.1161/CIRCRESAHA.116.304564

Circulating cells contribute to cardiomyocyte regeneration after injury

Jasmine M F Wu et al. Circ Res. 2015.

. 2015 Feb 13;116(4):633-41.

doi: 10.1161/CIRCRESAHA.116.304564. Epub 2014 Nov 14.

Authors

Jasmine M F Wu¹, Ying-Chang Hsueh¹, Hui-Ju Ch'ang¹, Chwan-Yau Luo¹, Li-Wha Wu¹, Hiromitsu Nakauchi¹, Patrick C H Hsieh²

Affiliations

¹ From the Institute of Basic Medical Sciences (J.M.F.W., Y.-C.H.) and Institute of Molecular Medicine (L.-W.W.), College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Surgery (C.-Y.L.) and Department of Radiation Oncology (H.-J.C.), National Cheng Kung University Hospital, Tainan, Taiwan; National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan (H.-J.C.); Division of Stem Cell Therapy, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan (H.N.); and Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan (P.C. H.H.).
² From the Institute of Basic Medical Sciences (J.M.F.W., Y.-C.H.) and Institute of Molecular Medicine (L.-W.W.), College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Surgery (C.-Y.L.) and Department of Radiation Oncology (H.-J.C.), National Cheng Kung University Hospital, Tainan, Taiwan; National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan (H.-J.C.); Division of Stem Cell Therapy, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan (H.N.); and Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan (P.C. H.H.). phsieh@ibms.sinica.edu.tw.

PMID: 25398235
DOI: 10.1161/CIRCRESAHA.116.304564

Abstract

Rationale: The contribution of bone marrow-borne hematopoietic cells to the ischemic myocardium has been documented. However, a pivotal study reported no evidence of myocardial regeneration from hematopoietic-derived cells. The study did not take into account the possible effect of early injury-induced signaling as the test mice were parabiotically paired to partners immediately after surgery-induced myocardial injury when cross-circulation has not yet developed.

Objective: To re-evaluate the role of circulating cells in the injured myocardium.

Methods and results: By combining pulse-chase labeling and parabiosis model, we show that circulating cells derived from the parabiont expressed cardiac-specific markers in the injured myocardium. Genetic fate mapping also revealed that circulating hematopoietic cells acquired cardiac cell fate by means of cell fusion and transdifferentiation.

Conclusions: These results suggest that circulating cells participate in cardiomyocyte regeneration in a mouse model of parabiosis when the circulatory system is fully developed before surgery-induced heart injury.

Keywords: blood circulation; cell fusion; cell transdifferentiation; parabiosis; regeneration; stem cells.

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Comment in

Circulating around the tissue: hematopoietic cell-based fusion versus transdifferentiation.
Quijada P, Sussman MA. Quijada P, et al. Circ Res. 2015 Feb 13;116(4):563-5. doi: 10.1161/CIRCRESAHA.115.305820. Circ Res. 2015. PMID: 25677514 Free PMC article. No abstract available.

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Circulating cells contribute to cardiomyocyte regeneration after injury

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Circulating cells contribute to cardiomyocyte regeneration after injury

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