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Review
. 2014 Aug 15;7(9):5404-14.
eCollection 2014.

Conserved type III secretion system exerts important roles in Chlamydia trachomatis

Wenting Dai  1 , Zhongyu Li  1
Affiliations
Review

Conserved type III secretion system exerts important roles in Chlamydia trachomatis

Wenting Dai et al. Int J Clin Exp Pathol. .

Abstract

Upon infection, Chlamydiae alter host cellular functions in a variety of ways. Chlamydial infection prevents host cell apoptosis, induces re-organization of the actin cytoskeleton and alters host cellular signaling mechanisms. Chlamydia is among the many pathogenic Gram-negative bacteria that employ the type III secretion system (T3SS) to overcome host defenses and exploit available resources. T3SS are used by many Gram-negative bacterial pathogens to manipulate eukaryotic host cells through the delivery of effector proteins into their cytosol and membranes. T3SS is an evolutionarily refined, virulence determinant of Gram-negative bacteria where more than 20 proteins form an apparatus, generally termed injectisome, to achieve the vectorial secretion and translocation of anti-host effector proteins. This review describes challenges and recent advances that have revealed how Chlamydia trachomatis utilizes diversification to produce a conserved T3SS that exerts an important role in Chlamydia trachomatis.

Keywords: Chlamydia trachomatis; chaperones; effectors; injectisomes; regulators; type III secretion system.

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Figures

Figure 1
Figure 1
Diagram of type III secretion system of Chlamydia trachomatis.
See this image and copyright information in PMC

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